Document Detail


Intermittent intraperitoneal infusion of peptide YY(3-36) reduces daily food intake and adiposity in obese rats.
MedLine Citation:
PMID:  17428898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peptide YY(3-36) [PYY(3-36)] is a gut-brain peptide that decreases food intake when administered by intravenous infusion to lean and obese humans and rats. However, chronic administration of PYY(3-36) by osmotic minipump to lean and obese rodents produces only a transient reduction in daily food intake and weight gain. It has recently been shown that 1-h intravenous infusions of PYY(3-36) every other hour for 10 days produced a sustained reduction in daily food intake, body weight, and adiposity in lean rats. Here, we determined whether intermittent delivery of PYY(3-36) can produce a similar response in diet-induced obese rats. During a 21-day period, obese rats (body fat >25%) received twice daily intraperitoneal infusion of vehicle (n = 18) or PYY(3-36) (n = 24) during hours 1-3 and 7-9 of the dark period. Rats had free access to both a 45% fat solid diet and a 29% fat liquid diet; intakes were determined from continuous computer recording of changes in food container weights. To sustain a 15-25% reduction in daily caloric intake, the initial PYY(3-36) dose of 30 pmol.kg(-1).min(-1) was reduced to 10 pmol.kg(-1).min(-1) on day 10 and then increased to 17 pmol.kg(-1).min(-1) on day 13. This dosing strategy produced a sustained reduction in daily caloric intake of 11-32% and prevented body weight gain (8 +/- 6 vs. 51 +/- 11 g) and fat deposition (4.4 +/- 7.6 vs. 41.0 +/- 12.8 g). These results indicate that intermittent intraperitoneal infusion of PYY(3-36) can produce a sustained reduction in food intake and adiposity in diet-induced obese rodents consuming palatable high-fat foods.
Authors:
Prasanth K Chelikani; Alvin C Haver; Roger D Reidelberger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-11
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  293     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-08-30     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R39-46     Citation Subset:  IM    
Affiliation:
Department of Veterans Affairs-Nebraska Western Iowa Health Care System, Research Service (151), 4101 Woolworth Ave., Omaha, NE 68105, USA.
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MeSH Terms
Descriptor/Qualifier:
Adiposity / drug effects*
Animals
Body Weight / drug effects
Diet
Dose-Response Relationship, Drug
Eating / drug effects*
Energy Intake / drug effects
Infusions, Intravenous
Infusions, Parenteral
Male
Obesity / drug therapy*,  physiopathology
Peptide YY / administration & dosage,  pharmacology*
Rats
Rats, Sprague-Dawley
Weight Gain / drug effects
Grant Support
ID/Acronym/Agency:
DK 55830/DK/NIDDK NIH HHS; DK 73152/DK/NIDDK NIH HHS; P20 RR 16469/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
106388-42-5/Peptide YY; 123583-37-9/peptide YY (3-36)
Comments/Corrections
Comment In:
Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R37-8   [PMID:  17491108 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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