Document Detail

Intermittent inhalation of nitrogen dioxide: effects on rabbit alveolar macrophages.
MedLine Citation:
PMID:  3573067     Owner:  NLM     Status:  MEDLINE    
Rabbits were exposed to 0.3 or 1 ppm NO2 for 2 h/d and the effects on alveolar macrophages recovered by bronchopulmonary lavage at 3 time points during the exposure series were assessed. Cells were examined 24 h after 2, 6, or 13 exposures, i.e., on d 3, 7, and 14. There was no change in the viability or numbers of macrophages recovered at any time, nor was an inflammatory response produced. The ability of macrophages to attach to a surface was not affected by exposure. Random mobility was reduced at d 3 in the 0.3 ppm exposure series, but was not different from control after any of the 1 ppm exposures. The phagocytic index, i.e., the fraction of viable cells able to phagocytize latex particles, was not affected by NO2 exposure. However, phagocytic capacity--i.e., the numbers of phagocytizing cells that internalized specific numbers of particles--was different from control on d 3 with both levels of NO2. At 0.3 ppm, particle uptake was reduced, while at 1 ppm it was enhanced in that a greater fraction of cells contained a large number of latex particles. The results show that phagocytic capacity and random mobility are sensitive indices of response to NO2 and that adaptation to the exposures apparently occurred in that both phagocytosis and mobility returned to control levels by d 7 and remained there through the duration of the exposure series.
R B Schlesinger
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  21     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1987  
Date Detail:
Created Date:  1987-06-01     Completed Date:  1987-06-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-39     Citation Subset:  IM    
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MeSH Terms
Administration, Inhalation
Cell Adhesion / drug effects
Cell Survival
Macrophages / cytology,  drug effects,  physiology*
Nitrogen Dioxide / administration & dosage,  pharmacology*
Phagocytosis / drug effects
Grant Support
Reg. No./Substance:
10102-44-0/Nitrogen Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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