Document Detail

Intermittent hypoxia mobilizes hematopoietic progenitors and augments cellular and humoral elements of innate immunity in adult men.
MedLine Citation:
PMID:  21962068     Owner:  NLM     Status:  MEDLINE    
This study tested the hypothesis that intermittent hypoxia treatment (IHT) modulates circulating hematopoietic stem and progenitor cells (HSPC) and augments humoral and cellular components of innate immunity in young, healthy men. Ten subjects (group 1: age 31±4 yr) were studied before and at 1 and 7 days after a 14-day IHT program consisting of four 5-min bouts/day of breathing 10% O2, lowering arterial O2 saturation to 84% to 85%, with intervening 5-min room-air exposures. Five more subjects (group 2: age 29±5 yr) were studied during 1 IHT session. Immunofluorescence detected HSPCs as CD45+CD34+ cells in peripheral blood. Phagocytic and bactericidal activities of neutrophils, circulating immunoglobulins (IgM, IgG, IgA), immune complexes, complement, and cytokines (erythropoietin, TNF-α, IL-4, IFN-γ) were measured. In group 1, the HSPC count fell 27% below pre-IHT baseline 1 week after completing IHT, without altering erythrocyte and reticulocyte counts. The IHT program also activated complement, increased circulating platelets, augmented phagocytic and bactericidal activities of neutrophils, sharply lowered circulating TNF-α and IL-4 by >90% and ∼75%, respectively, and increased IFN-γ, particularly 1 week after IHT. During acute IHT (group 2), HSPC increased by 51% after the second hypoxia bout and by 19% after the fourth bout, and total leukocyte, neutrophil, monocyte, and lymphocyte counts also increased; but these effects subsided by 30 min post-IHT. Collectively, these results demonstrate that IHT enhances innate immunity by mobilizing HSPC, activating neutrophils, and increasing circulating complement and immunoglobulins. These findings support the potential for eventual application of IHT for immunotherapy.
Tatiana V Serebrovskaya; Igor S Nikolsky; Valentyna V Nikolska; Robert T Mallet; Vadim A Ishchuk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  12     ISSN:  1557-8682     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-03     Completed Date:  2012-02-17     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-52     Citation Subset:  IM; S    
Bogomoletz Institute of Physiology, Kiev, Ukraine.
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MeSH Terms
Anoxia / blood,  immunology*,  physiopathology
Antigens, CD34
Antigens, CD45
Blood Bactericidal Activity
Blood Cell Count
Complement System Proteins / metabolism
Cytokines / blood*
Hematopoietic Stem Cells / cytology,  immunology*
Immunity, Innate* / physiology
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin M / blood
Neutrophils / immunology
Young Adult
Reg. No./Substance:
0/Antigens, CD34; 0/Cytokines; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 9007-36-7/Complement System Proteins; EC, CD45

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