Document Detail

Intermittent hypoxia increases ventilation and Sa(O2) during hypoxic exercise and hypoxic chemosensitivity.
MedLine Citation:
PMID:  11247944     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was 1) to test the hypothesis that ventilation and arterial oxygen saturation (Sa(O2)) during acute hypoxia may increase during intermittent hypoxia and remain elevated for a week without hypoxic exposure and 2) to clarify whether the changes in ventilation and Sa(O2) during hypoxic exercise are correlated with the change in hypoxic chemosensitivity. Six subjects were exposed to a simulated altitude of 4,500 m altitude for 7 days (1 h/day). Oxygen uptake (VO2), expired minute ventilation (VE), and Sa(O2) were measured during maximal and submaximal exercise at 432 Torr before (Pre), after intermittent hypoxia (Post), and again after a week at sea level (De). Hypoxic ventilatory response (HVR) was also determined. At both Post and De, significant increases from Pre were found in HVR at rest and in ventilatory equivalent for O2 (VE/VO2) and Sa(O2) during submaximal exercise. There were significant correlations among the changes in HVR at rest and in VE/VO2 and Sa(O2) during hypoxic exercise during intermittent hypoxia. We conclude that 1 wk of daily exposure to 1 h of hypoxia significantly improved oxygenation in exercise during subsequent acute hypoxic exposures up to 1 wk after the conditioning, presumably caused by the enhanced hypoxic ventilatory chemosensitivity.
K Katayama; Y Sato; Y Morotome; N Shima; K Ishida; S Mori; M Miyamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  90     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-05-31     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1431-40     Citation Subset:  IM    
Research Center of Health, Physical Fitness and Sports, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.
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MeSH Terms
Air Pressure
Anoxia / physiopathology*
Exercise / physiology*
Exercise Test
Heart Rate / physiology
Hypercapnia / physiopathology
Oxygen / blood
Oxygen Consumption / physiology*
Respiratory Function Tests
Respiratory Mechanics / physiology*
Reg. No./Substance:

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