Document Detail

Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease.
MedLine Citation:
PMID:  15262041     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intermittent hypoxia has been suggested to increase exercise tolerance by enhancing stress resistance and improving oxygen delivery. Because the improvement of exercise tolerance reduces mortality in the elderly with and without coronary artery disease intermittent hypoxia might be a valuable preventive and therapeutic tool. However, controlled studies are lacking. METHODS AND RESULTS: Sixteen males (50-70 years, 8 with and 8 without prior myocardial infarction) were randomly assigned in a double-blind fashion to receive 15 sessions of passive intermittent hypoxia (hypoxia group) or normoxia (control group) within 3 weeks. For the hypoxia group each session consisted of three to five hypoxic (14-10% oxygen) periods (3-5 min) with 3-min normoxic intervals. Controls inhaled only normoxic air in the same way. Exercise tests were performed before and after the 3-week breathing program. After 3 weeks of intermittent hypoxia peak oxygen consumption had increased compared to normoxic conditions (+ 6.2% vs.-3%, p < 0.001). This improvement was closely related to the enhanced arterial oxygen content after hypoxia (r = 0.9, p < 0.001). Both higher haemoglobin concentration and less arterial oxygen desaturation during exercise contributed to the increase in arterial oxygen content. During sub-maximal exercise (cycling at 1 W/kg) heart rate, systolic blood pressure, blood lactate concentration, and the rating of perceived exertion were diminished after intermittent hypoxia compared to control conditions (all p < 0.05). Changes in responses to exercise after intermittent hypoxia were similar in subjects with and without prior myocardial infarction. CONCLUSIONS: Three weeks of passive short-term intermittent hypoxic exposures increased aerobic capacity and exercise tolerance in elderly men with and without coronary artery disease.
Martin Burtscher; Otmar Pachinger; Igor Ehrenbourg; Günther Mitterbauer; Martin Faulhaber; Reinhard Pühringer; Elena Tkatchouk
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of cardiology     Volume:  96     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-20     Completed Date:  2004-12-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Elsevier Ireland Ltd.
Department of Sport Science, Medical Section, University of Innsbruck, Fürstenweg 185, 6020 Innsbruck, Austria.
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MeSH Terms
Coronary Artery Disease / physiopathology*
Double-Blind Method
Exercise / physiology*
Exercise Test
Exercise Tolerance / physiology*
Follow-Up Studies
Middle Aged
Oxygen Consumption / physiology
Reference Values
Risk Assessment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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