| Intermittent heparin infusion in children with ischemic heart disease caused by Kawasaki disease. | |
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MedLine Citation:
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PMID: 18243369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We determined change in serum hepatocyte growth factor (HGF), one of the most potent angiogenic factors, after intravenous infusion of heparin in children and reported successful improvement of cardiac ischemia after regular intravenous heparin infusion in an infant with ischemic heart disease (IHD) caused by Kawasaki disease (KD). Intravenous infusion of 50 units/kg of heparin significantly increased serum HGF from 0.8+/-0.6 to 8.4+/-3.4 at 5 min, 8.3+/-2.5 at 30 min, and 4.9+/-1.5 ng/ml at 60 min, respectively. Subsequently, a 16-month-old infant with IHD caused by KD had received regular intravenous infusion of heparin, 100 IU/kg twice a day for 1 month and once a week for subsequent 2 months. With this treatment, his perfusion defect on myocardial scintigraphy disappeared. In conclusion, regular heparin infusion alone can improve myocardial ischemia caused by KD, probably due to facilitated production of HGF. |
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Authors:
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Kenji Suda; Masahiko Mastumoto; Setsuko Miyanishi |
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Publication Detail:
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Type: Comparative Study; Letter Date: 2008-02-19 |
Journal Detail:
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Title: International journal of cardiology Volume: 133 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-06 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 417-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Catheters, Indwelling Child Child, Preschool Female Heparin / administration & dosage* Hepatocyte Growth Factor / blood Humans Infant Infusions, Intravenous Male Mucocutaneous Lymph Node Syndrome / blood, complications*, drug therapy* Myocardial Ischemia / blood, drug therapy*, etiology* |
| Chemical | |
Reg. No./Substance:
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67256-21-7/Hepatocyte Growth Factor; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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