Document Detail

Intermittent heparin infusion in children with ischemic heart disease caused by Kawasaki disease.
MedLine Citation:
PMID:  18243369     Owner:  NLM     Status:  MEDLINE    
We determined change in serum hepatocyte growth factor (HGF), one of the most potent angiogenic factors, after intravenous infusion of heparin in children and reported successful improvement of cardiac ischemia after regular intravenous heparin infusion in an infant with ischemic heart disease (IHD) caused by Kawasaki disease (KD). Intravenous infusion of 50 units/kg of heparin significantly increased serum HGF from 0.8+/-0.6 to 8.4+/-3.4 at 5 min, 8.3+/-2.5 at 30 min, and 4.9+/-1.5 ng/ml at 60 min, respectively. Subsequently, a 16-month-old infant with IHD caused by KD had received regular intravenous infusion of heparin, 100 IU/kg twice a day for 1 month and once a week for subsequent 2 months. With this treatment, his perfusion defect on myocardial scintigraphy disappeared. In conclusion, regular heparin infusion alone can improve myocardial ischemia caused by KD, probably due to facilitated production of HGF.
Kenji Suda; Masahiko Mastumoto; Setsuko Miyanishi
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Publication Detail:
Type:  Comparative Study; Letter     Date:  2008-02-19
Journal Detail:
Title:  International journal of cardiology     Volume:  133     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  417-9     Citation Subset:  IM    
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MeSH Terms
Catheters, Indwelling
Child, Preschool
Heparin / administration & dosage*
Hepatocyte Growth Factor / blood
Infusions, Intravenous
Mucocutaneous Lymph Node Syndrome / blood,  complications*,  drug therapy*
Myocardial Ischemia / blood,  drug therapy*,  etiology*
Reg. No./Substance:
67256-21-7/Hepatocyte Growth Factor; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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