Document Detail

Intermittent exercise test in chronic obstructive pulmonary disease patients: how do the pulmonary hemodynamics adapt?
MedLine Citation:
PMID:  15570136     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Endurance training is an important component of rehabilitation in patients with chronic obstructive pulmonary disease (COPD). In our study, we investigated the pulmonary hemodynamics' adaptation during a high-intensity intermittent exercise in such patients. METHODS: Eight patients underwent a 30-min exercise, alternating a 4-min work set at their first ventilatory threshold with a 1-min exercise set at 90% of their maximal tolerated power output. Pulmonary arterial pressure was measured by means of a right heart catheter. Cardiac output was calculated using the Fick's principle applied to oxygen. RESULTS: VO(2), cardiac output, and ventilation increased during the first minutes of exercise and remained stable thereafter. Heart rate increased significantly and progressively to its maximal value from rest to the end of the test (P < 0.001). After an initial increase, stroke volume decreased significantly (P < 0.05). Pulmonary arterial pressure increased from rest (mean +/- SEM 23.9 +/- 2.1 mm Hg) to the fifth minute of exercise (41.6 +/- 2.8 mm Hg), and decreased significantly thereafter (35.2 +/- 3.3 mm Hg at the 30th minute) (P < 0.001). Total pulmonary vascular resistance decreased from rest to the end of the test (P < 0.001). CONCLUSION: The high-intensity 1-min bouts of work of our intermittent work exercise are well tolerated without pushing the pulmonary arterial pressure dramatically high in COPD patients.
Evelyne Lonsdorfer-Wolf; Valérie Bougault; Stéphane Doutreleau; Anne Charloux; Jean Lonsdorfer; Monique Oswald-Mammosser
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  36     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-30     Completed Date:  2005-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2032-9     Citation Subset:  IM; S    
Department of Clinical Physiology and UPRES EA 3072, University Hospital of Strasbourg, BP 426, 67091 Strasbourg, France.
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MeSH Terms
Adaptation, Physiological*
Blood Pressure / physiology*
Cardiac Output
Exercise Test*
Exercise Therapy*
Heart Rate / physiology*
Middle Aged
Oxygen Consumption
Pulmonary Disease, Chronic Obstructive / complications,  physiopathology*,  rehabilitation*

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