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Intermittent Atrial Tachycardia Promotes Repolarization Alternans and Conduction Slowing During Rapid Rates, and increases Susceptibility to Atrial Fibrillation in a Free-behaving Sheep Model.
MedLine Citation:
PMID:  24383960     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Paroxysmal atrial fibrillation (AF) may be triggered by intermittent atrial tachycardia, and ultimately lead to persistent AF. However, the mechanisms by which intermittent atrial tachycardia promotes sustained AF are not well understood.
METHODS AND RESULTS: Eight sheep were chronically implanted with two pacemakers for the recording of broadband right atrial unipolar electrograms, and for the delivery of electrophysiological stimulation protocols and intermittent right atrial tachycardia. Right atrial kinetics of activation recovery interval (ARI) as a surrogate for action potential duration, of conduction time and velocity, and of repolarization alternans were analyzed at incremental pacing rates during the remodeling process induced by weeks of intermittent atrial tachycardia until the development of sustained AF. Intermittent atrial tachycardia decreased ARI and blunted its rate-adaptation, facilitated atrial capture and slowed conduction at high rates, and increased susceptibility to pacing-induced AF. In spite of blunted ARI rate-adaptation, right atrial repolarization alternans was maintained during remodeling, and further increased in magnitude just before rapid pacing-induced AF.
CONCLUSION: This study suggests that weeks of intermittent right atrial tachycardia result in a gradual electrical remodeling favorable for wavebreaks and reentry that may facilitate fibrillation. This article is protected by copyright. All rights reserved.
Joanna Monigatti-Tenkorang; Florian Jousset; Patrizio Pascale; Jean-Marc Vesin; Patrick Ruchat; Martin Fromer; Sanjiv M Narayan; Etienne Pruvot
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-2
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  -     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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