Document Detail


Intermedin 1-53 in central nervous system elevates arterial blood pressure in rats.
MedLine Citation:
PMID:  16023765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide (CGRP) family identified from human and other vertebrate tissues. Preprointermedin can generate various mature peptides by proteolytic cleavage. Amino acid sequence analysis showed cleavage sites located between two basic amino acids at Arg93-Arg94 resulting in the production of prepro-IMD(95-147), namely IMD(1-53). The present study was designed to determine the effects of the IMD(1-53) fragment in the central nervous system (CNS) on mean arterial blood pressure and heart rate in normal rats and its possible mechanism. Rats were given doses of adrenomedullin (ADM) or IMD(1-53), intracerebroventricularly or intravenously, respectively, with continuous blood pressure and heart rate monitoring for 45min. Analysis with CGRP receptor antagonist CGRP(8-37), ADM receptor antagonist ADM(22-52), and anti-prepro-IMD antibody showed that 0.1, 0.5, and 1.0 nmol/kg IMD(1-53), caused a dose-dependent elevation in blood pressure, which was more prominent than the increase with equivalent IMD(1-47) or ADM. As well, IMD(1-53) caused a persistent increase in heart rate. The CNS action of IMD(1-53) could be blocked by ADM(22-52), CGRP(8-37), or prepro-IMD antibody. In contrast to the CNS action, intravenous administration of IMD(1-53) induced a depressor effect. These results suggest that IMD(1-53) is an important regulatory factor in mean arterial blood pressure and heart rate through its central and peripheral bioaction.
Authors:
Yong-Sheng Ren; Jing-Hui Yang; Jing Zhang; Chun-Shui Pan; Jun Yang; Jing Zhao; Yong-Zheng Pang; Chao-Shu Tang; Yong-Fen Qi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-07-14
Journal Detail:
Title:  Peptides     Volume:  27     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-13     Completed Date:  2009-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-9     Citation Subset:  IM    
Affiliation:
Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China.
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin / physiology*
Animals
Blood Pressure / physiology*
Calcitonin Gene-Related Peptide / physiology
Central Nervous System / physiology*
Immune Sera
Injections, Intravenous
Injections, Intraventricular
Neuropeptides / physiology*
Peptide Fragments / physiology*
Rats
Chemical
Reg. No./Substance:
0/Immune Sera; 0/Neuropeptides; 0/Peptide Fragments; 0/adrenomedullin (22-52); 0/intermedin protein, rat; 119911-68-1/calcitonin gene-related peptide (8-37); 148498-78-6/Adrenomedullin; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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