Document Detail

Intermediate and long-term outcome of patients after device closure of ASD with special reference to complications.
MedLine Citation:
PMID:  20929028     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Device closure of Secundum atrial septal defect (ASD) is an accepted mode of treatment in selected patients with a suitable defect. The major initial concern over the long-term outcome has been erosions and more recently development of aortic regurgitation. Objective was to assess the intermediate and long term outcome of patients with device closure of ASD with special reference to complications. METHODS: Two hundred and four patients with significant Secundum ASD, 16 months to 55 years (median 8 years) were considered for transcatheter closure with the Amplatzer septal occluder from October 1999 to April 2009 with follow up examinations at 1, 3, 6, and 12 months and thereafter at yearly interval. RESULTS: Device closure of ASD was done successfully in 202/204 patients. The immediate (first 24-hour) major complications included device embolization (n = 4), pericardial effusion (n = 1) and 2:1 heart block (n = 1). At a mean follow up of 4.9 years (90 days to 9.6 years, median 5.3 years) complete closure was documented in all patients. Two patients (1%) had developed mild aortic regurgitation. Atrial fibrillation occurred in 3 adult patients (1.5%) at a mean of 2 weeks post procedure with complete recovery within 6 months. There were no late embolizations, erosions or thromboembolic events on long-term follow up. CONCLUSIONS: Device closure of Secundum ASD using Amplatzer septal occluder is safe and effective in intermediate and long-term follow up with extremely low mortality rate. The risk of development of aortic regurgitation or atrial fibrillation is also very low.
Tehmina Kazmi; Masood Sadiq; Asif-ur-Rehman; Najam Hyder; Farhan Latif
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of Ayub Medical College, Abbottabad : JAMC     Volume:  21     ISSN:  1025-9589     ISO Abbreviation:  J Ayub Med Coll Abbottabad     Publication Date:    2009 Jul-Sep
Date Detail:
Created Date:  2010-10-08     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910750     Medline TA:  J Ayub Med Coll Abbottabad     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Department of Paediatric Cardiology, The Children's Hospital and Institute of Child Health, Lahore, Pakistan.
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MeSH Terms
Child, Preschool
Heart Septal Defects, Atrial / surgery*
Middle Aged
Pakistan / epidemiology
Postoperative Complications / epidemiology
Septal Occluder Device*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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