| Intermediate and long-term memory are different at the neuronal level in Lymnaea stagnalis (L.). | |
| | |
MedLine Citation:
|
PMID: 21757019 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Both intermediate-term memory (ITM) and long-term memory (LTM) require novel protein synthesis; however, LTM also requires gene transcription. This suggests that the behavioural output of the two processes may be produced differently at the neuronal level. The fresh-water snail, Lymnaea stagnalis, can be operantly conditioned to decrease its rate of aerial respiration and, depending on the training procedure, the memory can last 3h (ITM) or >24h (LTM). RPeD1, one of the 3 interneurons that form the respiratory central pattern generator (CPG) that drives aerial respiration, is necessary for memory formation. By comparing RPeD1's electrophysiological properties in naïve, 'ITM-trained', 'LTM-trained' and yoked control snails we discovered that while the behavioural phenotype of memory at 3 and 24h is identical, the situation at the neuronal level is different. When examined 3h after either the 'ITM' or 'LTM' training procedure RPeD1 activity is significantly depressed. That is, the firing rate, input resistance, excitability and the number of action potential bursts are all significantly decreased. In snails receiving the ITM-training, these changes return to normal 24h post-training. However, in snails receiving the 'LTM-training', measured RPeD1 properties (firing rate, excitability, membrane resistance, and the number of action potential bursts fired) are significantly different at 24h than they were at 3h. Additionally, 24h following LTM training RPeD1 appears to be functionally "uncoupled" from its control of the pneumostome as the link between RPeD1 excitation and pneumostome opening is weakened. These data suggest that the behavioural changes occurring during LTM are due to more widespread neuronal reorganization than similar behavioural changes occurring during ITM. Thus ITM and LTM are not just distinct in a chronological and transcriptional manner but are also distinct at the level of neuronal properties. |
| | |
Authors:
|
Marvin H Braun; Ken Lukowiak |
Related Documents
:
|
19948529 - A novel dance dance revolution (ddr) system for in-home training of stepping ability: b... 6848589 - Context utilization in young and old adults. 21989739 - Visual mental image generation does not overlap with visual short-term memory: a dual-t... 22067609 - Memory impairment induced by brain iron overload is accompanied by reduced h3k9 acetyla... 21738519 - Transfer of training between music and speech: common processing, attention, and memory. 21856569 - Consciousness and cell memory: a dynamic epigenetic interrelationship. 22368969 - Influence of carvedilol on anticonvulsant effect of gabapentin. 21069779 - Postnatal alterations in induction threshold and expression magnitude of long-term pote... 16012639 - Meg analysis of "theory of mind" in emotional vignettes comprehension. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-3 |
Journal Detail:
|
Title: Neurobiology of learning and memory Volume: - ISSN: 1095-9564 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508166 Medline TA: Neurobiol Learn Mem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
|
Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada T2N 4N1. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Two novel 5-HT(6) receptor antagonists ameliorate scopolamine-induced memory deficits in the object ...
Next Document: Chemotactic behavior of Campylobacter spp. in function of different temperatures (37 °C and 42 °...