| Intermediate fixed coronary artery stenosis at the site of ergonovine-provoked spasm as a predictor of long-term major adverse cardiac events of patients with coronary spastic angina. | |
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MedLine Citation:
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PMID: 19225205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Organic coronary artery stenosis is a significant prognostic factor in patients with coronary spastic angina (CSA), so the present study was focused on assessing the impact of intermediate fixed stenosis at sites of provoked spasm on the long-term outcomes of CSA patients. METHODS AND RESULTS: CSA patients diagnosed on the basis of ergonovine-provoked spasm were enrolled and the clinical background and long-term prognosis of CSA patients with intermediate fixed stenosis at the site of provoked spasm (with-fixed-stenosis group, n=37) and those without fixed stenosis (without-fixed-stenosis group, n=126) were retrospectively compared. During the follow-up period (average 4.01 years for with-fixed-stenosis, 4.47 years for without-fixed-stenosis), the with-fixed-stenosis group had a significantly lower event-free survival rate, as well as a higher frequency of admission for unstable angina and percutaneous coronary intervention than the without-fixed-stenosis group, whereas the survival rate did not differ significantly between the 2 groups. In the multivariate analysis, intermediate fixed stenosis at the site of provoked spasm was a predictor of long-term major adverse cardiac events (MACE). CONCLUSIONS: Intermediate fixed stenosis at the site of ergonovine-provoked spasm is an independent risk factor for MACE during the long-term period in CSA patients. |
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Authors:
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Shinya Nishizawa; Jun Shiraishi; Sayuki Torii; Kotaro Miyagawa; Masayasu Arihara; Mitsuyoshi Hadase; Masayuki Hyogo; Takakazu Yagi; Takatomo Shima; Yoshio Kohno; Hiroaki Matsubara |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-02-18 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-25 Completed Date: 2009-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 699-704 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, and Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto, Japan. nshinya@koto.kpu-m.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / mortality* Coronary Stenosis / chemically induced, mortality* Coronary Vessels* Disease-Free Survival Ergonovine / administration & dosage, adverse effects* Female Follow-Up Studies Humans Male Middle Aged Oxytocics / administration & dosage, adverse effects* Retrospective Studies Spasm / chemically induced, mortality* Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 60-79-7/Ergonovine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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