Document Detail


Intermediate fixed coronary artery stenosis at the site of ergonovine-provoked spasm as a predictor of long-term major adverse cardiac events of patients with coronary spastic angina.
MedLine Citation:
PMID:  19225205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Organic coronary artery stenosis is a significant prognostic factor in patients with coronary spastic angina (CSA), so the present study was focused on assessing the impact of intermediate fixed stenosis at sites of provoked spasm on the long-term outcomes of CSA patients. METHODS AND RESULTS: CSA patients diagnosed on the basis of ergonovine-provoked spasm were enrolled and the clinical background and long-term prognosis of CSA patients with intermediate fixed stenosis at the site of provoked spasm (with-fixed-stenosis group, n=37) and those without fixed stenosis (without-fixed-stenosis group, n=126) were retrospectively compared. During the follow-up period (average 4.01 years for with-fixed-stenosis, 4.47 years for without-fixed-stenosis), the with-fixed-stenosis group had a significantly lower event-free survival rate, as well as a higher frequency of admission for unstable angina and percutaneous coronary intervention than the without-fixed-stenosis group, whereas the survival rate did not differ significantly between the 2 groups. In the multivariate analysis, intermediate fixed stenosis at the site of provoked spasm was a predictor of long-term major adverse cardiac events (MACE). CONCLUSIONS: Intermediate fixed stenosis at the site of ergonovine-provoked spasm is an independent risk factor for MACE during the long-term period in CSA patients.
Authors:
Shinya Nishizawa; Jun Shiraishi; Sayuki Torii; Kotaro Miyagawa; Masayasu Arihara; Mitsuyoshi Hadase; Masayuki Hyogo; Takakazu Yagi; Takatomo Shima; Yoshio Kohno; Hiroaki Matsubara
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-02-18
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-25     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  699-704     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, and Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto, Japan. nshinya@koto.kpu-m.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / mortality*
Coronary Stenosis / chemically induced,  mortality*
Coronary Vessels*
Disease-Free Survival
Ergonovine / administration & dosage,  adverse effects*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Oxytocics / administration & dosage,  adverse effects*
Retrospective Studies
Spasm / chemically induced,  mortality*
Survival Rate
Chemical
Reg. No./Substance:
0/Oxytocics; 60-79-7/Ergonovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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