Document Detail


Intermediate filaments of human trophoblast and choriocarcinoma cell lines.
MedLine Citation:
PMID:  2411047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human term placenta and two human choriocarcinoma cell lines were studied immunohistochemically and by immunoblotting with monoclonal antibodies to keratin polypeptides and vimentin. Four keratin polypeptides (40, 45, 52, 54 K) were detected in both normal and malignant trophoblastic cells. The presence of the 54 K keratin polypeptide distinguishes the benign and malignant trophoblastic cells from human embryonal carcinoma cells and a yolk sac carcinoma cell line.
Authors:
R K Clark; I Damjanov
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  407     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1985  
Date Detail:
Created Date:  1985-09-25     Completed Date:  1985-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Choriocarcinoma / metabolism*,  pathology,  ultrastructure
Cytoskeleton / metabolism*
Dysgerminoma / metabolism
Electrophoresis
Female
Histocytochemistry
Humans
Immunochemistry
Keratins / metabolism*
Peptides / metabolism
Pregnancy
Trophoblasts / cytology,  metabolism*,  ultrastructure
Vimentin / metabolism
Grant Support
ID/Acronym/Agency:
CA 23097/CA/NCI NIH HHS; CA 38405/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Peptides; 0/Vimentin; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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