Document Detail


Interleukins and atherosclerosis: a dysfunctional family grows.
MedLine Citation:
PMID:  24206661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.
Authors:
Larry D Spears; Babak Razani; Clay F Semenkovich
Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cell metabolism     Volume:  18     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-11     Completed Date:  2014-06-05     Revised Date:  2014-11-06    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atherosclerosis / metabolism*
Fatty Acids / metabolism*
Female
Humans
Inflammasomes / metabolism*
Interleukin-1alpha / metabolism*
Mitochondria / metabolism*
Vasculitis / metabolism*
Grant Support
ID/Acronym/Agency:
DK076729/DK/NIDDK NIH HHS; DK088083/DK/NIDDK NIH HHS; K08 HL098559/HL/NHLBI NIH HHS; K08 HL098559/HL/NHLBI NIH HHS; R01 DK076729/DK/NIDDK NIH HHS; R01 DK088083/DK/NIDDK NIH HHS; T32 DK007120/DK/NIDDK NIH HHS; T32 DK007120/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Inflammasomes; 0/Interleukin-1alpha
Comments/Corrections
Comment On:
Nat Immunol. 2013 Oct;14(10):1045-53   [PMID:  23995233 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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