| Interleukin (IL)-6 and IL-1 beta act synergistically within the brain to induce sickness behavior and fever in rats. | |
| | |
MedLine Citation:
|
PMID: 18255258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pro-inflammatory cytokines interleukin (IL)-6 and IL-1 beta can act in the brain (centrally) to cause fever. Sickness behaviors which accompany fever also appear to involve the central action of IL-1 beta. We injected species-homologous rat IL-6 and IL-1 beta directly into the brains of conscious rats to examine the effect of these cytokines on fever, and two behaviors affected by sickness, voluntary wheel-running and food intake. Male Sprague-Dawley rats selected for their predisposition to spontaneously run on running wheels were used in the experiment. Each rat was anaesthetized and had a temperature-sensitive radiotransmitter implanted intra-abdominally, and a 23-gauge stainless steel guide cannula inserted stereotaxically over the lateral cerebral ventricle. Rats were randomly assigned to receive intracerebroventricular injections of three doses of either IL-1 beta or IL-6 (100 ng, 1 ng or 0.1 ng IL-1 beta and 200 ng, 20 ng or 2 ng IL-6), or one of three different combinations of IL-1 beta and IL-6. Rats receiving either IL-1 beta or IL-6 showed a dose-dependent increase in body temperature and decrease in wheel-running (ANOVA, p<0.0001). Only rats receiving the highest dose of IL-1 beta significantly decreased food intake and body mass compared to rats receiving vehicle (ANOVA, p<0.001). Doses of IL-1 beta and IL-6 which, when injected on their own were non-pyrogenic and did not affect food intake and body mass, induced fever and anorexia when they were co-injected centrally. These results show that species-homologous rat IL-6 and IL-1 beta can act directly within the brain to decrease voluntary activity and suggest they also can act synergistically to induce anorexia and fever. |
| | |
Authors:
|
Lois M Harden; Irné du Plessis; Stephen Poole; Helen P Laburn |
Related Documents
:
|
2943138 - Liver and brain mitochondrial atpase activities in rats exposed to high ambient tempera... 15677528 - Effect of a high or low ambient perinatal temperature on adult obesity in osborne-mende... 16455768 - Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the p... 935208 - Heat-escape behavior in the rat following intrahypothalamic injection of acetylcholine. 1439598 - Autotransposition of vas in a 2-stage procedure. an experimental study in the rat. 2943138 - Liver and brain mitochondrial atpase activities in rats exposed to high ambient tempera... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-05 |
Journal Detail:
|
Title: Brain, behavior, and immunity Volume: 22 ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-07-08 Completed Date: 2008-08-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
|
Languages: eng Pagination: 838-49 Citation Subset: IM |
Affiliation:
|
Brain Function Research Group, School of Physiology, Medical School, University of the Witwatersrand, 7 York Road, Parktown, Gauteng, Johannesburg, South Africa. Lois.Harden@wits.ac.za |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Anorexia / chemically induced, physiopathology Behavior, Animal / drug effects* Body Temperature / drug effects Body Weight / drug effects Brain / drug effects*, physiopathology Dose-Response Relationship, Drug Drug Synergism Eating / drug effects Fever / chemically induced* Injections, Intraventricular Interleukin-1beta / administration & dosage, toxicity* Interleukin-6 / administration & dosage, toxicity* Male Motor Activity / drug effects Rats Rats, Sprague-Dawley Sick Role |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-1beta; 0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Latitudinal variation of immune defense and sickness behavior in the white-crowned sparrow (Zonotric...
Next Document: Effects of perinatal oxycodone exposure on the response to CRH in late adolescent rats.