Document Detail


Interleukin 8 and susceptibility to coronary artery disease: a population genetics perspective.
MedLine Citation:
PMID:  18385984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Interleukin 8 is a strong chemoattractant factor for neutrophils and T lymphocytes. We investigated the potential influence of two common polymorphisms of the interleukin-8 gene, -251A/T, and 781C/T on susceptibility to coronary artery disease. MATERIALS AND METHODS: The hypothesis was tested by screening for the prevalence of the above polymorphisms in 241 angiographically diagnosed coronary artery disease patients compared to 157 selected controls with negative coronary angiography. RESULTS AND DISCUSSION: We found no significant differences between cases and controls concerning the allelic and genotypic frequencies of both the studied polymorphisms. Nevertheless, a statistically significant lower frequency of the AA containing genotypes was observed in cases presenting with acute coronary syndromes compared to asymptomatic subjects or patients with stable coronary artery disease (OR = 0.44, 95%CI: 0.2-0.98, p = 0.04). The strongest statistical significance was observed in the AA(251)TT(781) combined genotype (OR = 0.34, 95%CI: 0.14-0.85, p = 0.02). CONCLUSION: Our results suggest that the genetic diversity of the interleukin-8 gene influences the clinical manifestation of CAD.
Authors:
Konstantina Vogiatzi; Stavros Apostolakis; Vassilios Voudris; Sophia Thomopoulou; Georgios E Kochiadakis; Demetrios A Spandidos
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Publication Detail:
Type:  Journal Article     Date:  2008-04-02
Journal Detail:
Title:  Journal of clinical immunology     Volume:  28     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-35     Citation Subset:  IM    
Affiliation:
Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
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MeSH Terms
Descriptor/Qualifier:
Aged
Base Sequence
Case-Control Studies
Coronary Angiography
Coronary Artery Disease / genetics*,  pathology*
Female
Genetic Predisposition to Disease*
Genetics, Population
Genotype
Humans
Interleukin-8 / genetics*
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
0/Interleukin-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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