Document Detail

Interleukin-8 release from human gestational tissue explants: effects of gestation, labor, and chorioamnionitis.
MedLine Citation:
PMID:  10456863     Owner:  NLM     Status:  MEDLINE    
Interleukin-8 (IL-8) is a chemotactic cytokine that has been implicated in the process of human parturition, including the processes of cervical ripening and rupture of fetal membranes. In this study, the in vitro release of IL-8 from human amnion, choriodecidua, and placenta tissues obtained before and after spontaneous labor onset both at term and preterm, was assessed. The effect of chorioamnionitis on IL-8 release was also established. All tissue explants examined released IL-8; however, IL-8 release from choriodecidual explants was significantly (p < 0.02) greater than that observed from amnion and placenta. Furthermore, choriodecidual IL-8 release was significantly (p < 0.001) greater from term tissues (850 +/- 134.4 ng/mg DNA, n = 18) than from preterm tissues (458 +/- 68.8 ng/mg DNA, n = 17). Spontaneous onset of labor, irrespective of the eventual mode of delivery, was not associated with any significant changes in IL-8 release from human gestational tissues compared to not-in-labor tissues, both at term and preterm. IL-8 release from gestational tissues was not significantly different in the absence or presence of chorioamnionitis. These data are in contrast to the previously reported stimulatory effects of bacterial endotoxin on IL-8 release from human gestational tissues. The data are consistent, however, with the suggestion that IL-8 release is an early event in chorioamnionitis that precedes the appearance of clinically overt symptoms.
N Laham; S P Brennecke; G E Rice
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of reproduction     Volume:  61     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-20     Completed Date:  1999-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  823-7     Citation Subset:  IM    
Perinatal Research Centre, Department of Perinatal Medicine, University of Melbourne, The Royal Women's Hospital, Carlton, Victoria, 3053, Australia.
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MeSH Terms
Amnion / secretion
Chorioamnionitis / physiopathology*
Chorion / secretion
Culture Techniques
Decidua / secretion
Extraembryonic Membranes / secretion*
Gestational Age*
Interleukin-8 / secretion*
Labor, Obstetric / physiology*
Placenta / secretion
Reg. No./Substance:

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