Document Detail


Interleukin-8 release from human gestational tissue explants: effects of gestation, labor, and chorioamnionitis.
MedLine Citation:
PMID:  10456863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin-8 (IL-8) is a chemotactic cytokine that has been implicated in the process of human parturition, including the processes of cervical ripening and rupture of fetal membranes. In this study, the in vitro release of IL-8 from human amnion, choriodecidua, and placenta tissues obtained before and after spontaneous labor onset both at term and preterm, was assessed. The effect of chorioamnionitis on IL-8 release was also established. All tissue explants examined released IL-8; however, IL-8 release from choriodecidual explants was significantly (p < 0.02) greater than that observed from amnion and placenta. Furthermore, choriodecidual IL-8 release was significantly (p < 0.001) greater from term tissues (850 +/- 134.4 ng/mg DNA, n = 18) than from preterm tissues (458 +/- 68.8 ng/mg DNA, n = 17). Spontaneous onset of labor, irrespective of the eventual mode of delivery, was not associated with any significant changes in IL-8 release from human gestational tissues compared to not-in-labor tissues, both at term and preterm. IL-8 release from gestational tissues was not significantly different in the absence or presence of chorioamnionitis. These data are in contrast to the previously reported stimulatory effects of bacterial endotoxin on IL-8 release from human gestational tissues. The data are consistent, however, with the suggestion that IL-8 release is an early event in chorioamnionitis that precedes the appearance of clinically overt symptoms.
Authors:
N Laham; S P Brennecke; G E Rice
Related Documents :
3326393 - Induction of labor and cervical ripening with oral pge2 in risk pregnancies. a placebo-...
22424603 - Molecular basis of type i antithrombin deficiency in two women with recurrent venous th...
8222593 - Inflammatory bowel disease in the pregnant woman.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of reproduction     Volume:  61     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-20     Completed Date:  1999-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  823-7     Citation Subset:  IM    
Affiliation:
Perinatal Research Centre, Department of Perinatal Medicine, University of Melbourne, The Royal Women's Hospital, Carlton, Victoria, 3053, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amnion / secretion
Chorioamnionitis / physiopathology*
Chorion / secretion
Culture Techniques
Decidua / secretion
Extraembryonic Membranes / secretion*
Female
Gestational Age*
Humans
Interleukin-8 / secretion*
Labor, Obstetric / physiology*
Placenta / secretion
Pregnancy
Chemical
Reg. No./Substance:
0/Interleukin-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Completion of meiosis is not always required for acrosome formation in HSP70-2 null mice.
Next Document:  Male pronuclear formation in denuded porcine oocytes after in vitro maturation in the presence of cy...