| Interleukin-8 levels and granulocyte counts in cervical mucus during pregnancy. | |
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MedLine Citation:
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PMID: 10735598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: We measured interleukin-8 (IL-8) and granulocyte counts in cervical mucus to assess local immunity and parturition. METHOD OF STUDY: We detected IL-8 by enzyme linked immunosorbent assay (ELISA) and Western blotting. Granulocytes were counted on a slide glass containing mucus from the external cervical os. RESULTS: ELISA and Western blotting revealed IL-8 in cervical mucus from both nonpregnant and pregnant women. There were no significant differences in cervical mucus IL-8 levels or granulocyte counts between follicular, ovulatory, and luteal phases. However, IL-8 and granulocyte counts were significantly decreased after menopause. IL-8 and granulocyte counts were increased significantly during pregnancy, and were further increased after 38 weeks of gestation and at labor. IL-8 levels were significantly correlated with granulocyte counts, based on the study of 678 samples (P <0.0001). CONCLUSION: IL-8 is involved in the increase of cervical granulocytes and in the process of parturition. |
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Authors:
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L Luo; T Ibaragi; M Maeda; M Nozawa; T Kasahara; M Sakai; Y Sasaki; K Tanebe; S Saito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 43 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-06-05 Completed Date: 2000-06-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 78-84 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Beijing Hospital, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blotting, Western Cervix Mucus / cytology, immunology* Enzyme-Linked Immunosorbent Assay Female Granulocytes / cytology, immunology, metabolism* Humans Interleukin-8 / metabolism* Leukocyte Count Middle Aged Postpartum Period / metabolism Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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