Document Detail

Interleukin-8 in cerebrospinal fluid from patients with septic and aseptic meningitis.
MedLine Citation:
PMID:  8801091     Owner:  NLM     Status:  MEDLINE    
Using a monoclonal antibody enzyme immunoassay, the concentration of interleukin-8 (IL-8) in cerebrospinal fluid (CSF) from 52 patients suspected of having meningitis was studied. The CSF IL-8 concentration was significantly higher in septic meningitis of known and unknown etiology than in aseptic meningitis and significantly higher in aseptic meningitis than in patients without meningitis. The CSF levels of IL-8 correlated with the levels of tumor necrosis factor-alpha, leukocyte count, neutrophil count, protein level, CSF/blood glucose ratio, and the number of days patients were hospitalized. The IL-8 values used to distinguish septic from aseptic meningitis, at a cut-off point of 3.00 micrograms/l, showed a sensitivity of 81%, a specificity of 92%, and a positive predictive value of 96%. The results suggest that determining IL-8 levels may be useful in the differential diagnosis of meningitis.
C Ostergaard; T L Benfield; F Sellebjerg; G Kronborg; N Lohse; J D Lundgren
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  15     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-10-01     Completed Date:  1996-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  166-9     Citation Subset:  IM    
Department of Clinical Microbiology, Statens Seruminstitut, Copenhagen, Denmark.
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MeSH Terms
Aged, 80 and over
Bacteremia / diagnosis
Child, Preschool
Diagnosis, Differential
Interleukin-8 / cerebrospinal fluid*
Meningitis, Aseptic / cerebrospinal fluid*,  diagnosis,  immunology
Meningitis, Bacterial / cerebrospinal fluid*,  diagnosis,  immunology
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Tumor Necrosis Factor-alpha / cerebrospinal fluid
Reg. No./Substance:
0/Interleukin-8; 0/Tumor Necrosis Factor-alpha

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