| Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection. | |
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MedLine Citation:
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PMID: 8677789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to elucidate the role of interleukin 8 (IL-8) in the development of chronic lung disease (CLD) of neonates with intra-uterine infection, serial and simultaneous measurements of the concentration of IL-8 and granulocyte elastase alpha 1 proteinase inhibitor complex (E-alpha 1 PI) in the tracheobronchial aspirate of low birth weight infants were conducted. Infants with a high serum IgM level at birth, and who subsequently developed CLD, showed significantly high concentrations of IL-8 and E-alpha 1 PI in the first 48 h. It seemed that IL-8 stimulated neutrophils to release neutrophil enzymes which, in turn, caused the lung tissue injury, resulting in the development of CLD following intra-uterine infection. |
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Authors:
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J Takasaki; Y Ogawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica Japonica; Overseas edition Volume: 38 ISSN: 0374-5600 ISO Abbreviation: Acta Paediatr Jpn Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-08-09 Completed Date: 1996-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370357 Medline TA: Acta Paediatr Jpn Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 132-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Saitama Medical Center, Saitama Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchi
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metabolism* Fetal Diseases* Granulocytes / enzymology* Humans Infant, Low Birth Weight Infant, Newborn Infection / complications* Interleukin-8 / metabolism* Leukocyte Elastase* Lung Diseases, Obstructive / etiology, metabolism* Pancreatic Elastase / metabolism* Suction Trachea / metabolism* alpha 1-Antitrypsin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-8; 0/alpha 1-Antitrypsin; 0/alpha 1-antitrypsin-leukocyte elastase complex; EC 3.4.21.36/Pancreatic Elastase; EC 3.4.21.37/Leukocyte Elastase |
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