Document Detail

Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection.
MedLine Citation:
PMID:  8677789     Owner:  NLM     Status:  MEDLINE    
In order to elucidate the role of interleukin 8 (IL-8) in the development of chronic lung disease (CLD) of neonates with intra-uterine infection, serial and simultaneous measurements of the concentration of IL-8 and granulocyte elastase alpha 1 proteinase inhibitor complex (E-alpha 1 PI) in the tracheobronchial aspirate of low birth weight infants were conducted. Infants with a high serum IgM level at birth, and who subsequently developed CLD, showed significantly high concentrations of IL-8 and E-alpha 1 PI in the first 48 h. It seemed that IL-8 stimulated neutrophils to release neutrophil enzymes which, in turn, caused the lung tissue injury, resulting in the development of CLD following intra-uterine infection.
J Takasaki; Y Ogawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  38     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-08-09     Completed Date:  1996-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  132-6     Citation Subset:  IM    
Department of Pediatrics, Saitama Medical Center, Saitama Medical School, Japan.
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MeSH Terms
Bronchi / metabolism*
Fetal Diseases*
Granulocytes / enzymology*
Infant, Low Birth Weight
Infant, Newborn
Infection / complications*
Interleukin-8 / metabolism*
Leukocyte Elastase*
Lung Diseases, Obstructive / etiology,  metabolism*
Pancreatic Elastase / metabolism*
Trachea / metabolism*
alpha 1-Antitrypsin / metabolism*
Reg. No./Substance:
0/Interleukin-8; 0/alpha 1-Antitrypsin; 0/alpha 1-antitrypsin-leukocyte elastase complex; EC Elastase; EC Elastase

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