Document Detail

Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes.
MedLine Citation:
PMID:  17212664     Owner:  NLM     Status:  MEDLINE    
AIM: Various predictive markers for preterm delivery have been proposed in previous studies. We investigated which marker is most reliable. METHODS: In 126 patients with preterm labor before 32 weeks of gestation and intact membranes, who had regular uterine contractions with cervical changes effaced > or =50%, we evaluated seven markers: interleukin (IL)-8, glucose, and granulocyte count in amniotic fluid (AF); fetal fibronectin (fFN) in vaginal secretions; IL-8 in cervical mucus; cervical length; and preterm labor index (PLI) based on clinical variables. The relationships of these variables to the occurrence of preterm delivery before 34 weeks were examined by logistic regression analysis. RESULTS: Values for AF IL-8, AF granulocyte count, fFN in vaginal secretions, and PLI were significantly higher, while the value for AF glucose was significantly lower, in patients delivering before 34 weeks than those in patients delivering at or following 34 weeks (P < 0.0001 for all). The most sensitive marker for predicting delivery before 34 weeks was AF IL-8 (sensitivity, 67.8%). The most specific markers were AF IL-8 (specificity, 95.5%) and PLI (specificity, 95.5%). By the logistic regression analysis, AF IL-8, AF glucose, fFN in vaginal secretions and PLI showed independent relationships with delivery before 34 weeks (P = 0.0009, P = 0.0032, P = 0.0131 and P = 0.0038, respectively). CONCLUSIONS: In preterm labor with intact membranes, AF IL-8, AF glucose, fFN in vaginal secretions and PLI were highly predictive markers for detecting preterm delivery before 34 weeks.
Satoshi Yoneda; Masatoshi Sakai; Yasushi Sasaki; Arihiro Shiozaki; Takao Hidaka; Shigeru Saito
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  33     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-10     Completed Date:  2007-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Toyama University, Toyama, Japan.
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MeSH Terms
Amniotic Fluid / chemistry*
Biological Markers / analysis
Extraembryonic Membranes
Fetal Proteins / analysis*,  secretion
Fibronectins / analysis*,  secretion
Glucose / analysis*
Interleukin-8 / analysis*
Obstetric Labor, Premature / diagnosis*
Predictive Value of Tests
Retrospective Studies
Vagina / chemistry*,  secretion
Reg. No./Substance:
0/Biological Markers; 0/Fetal Proteins; 0/Fibronectins; 0/Interleukin-8; 50-99-7/Glucose

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