| Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. | |
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MedLine Citation:
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PMID: 12415593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the influence of interleukin-8 (IL-8), epithelial cell-derived neutrophil-activating peptide (ENA-78), and regulated upon activation normal T cell expressed and secreted (RANTES) gene polymorphisms in the susceptibility and clinical expression of patients fulfilling classification criteria for Henoch-Schönlein purpura (HSP). METHODS: Fifty patients (25 men) from Northwest Spain with primary cutaneous vasculitis classified as HSP according to proposed criteria were studied. All patients were required to have had at least 2 years' followup. Patients and ethnically matched controls were genotyped for IL-8, ENA-78, and RANTES gene polymorphisms. RESULTS: No allele or genotype differences between patients fulfilling HSP classification criteria and controls were observed for any of the chemokines. However, a significantly increased frequency of allele A of the IL-8 gene polymorphism was found in patients with HSP who developed renal manifestations compared with patients without renal involvement (p = 0.02; pcorr = 0.036). Moreover, the genotype distribution in HSP patients with and without renal involvement showed statistically significant differences (p = 0.02). CONCLUSION: In unselected patients with cutaneous vasculitis, carriage of IL-8 allele A influences the susceptibility to renal involvement. |
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Authors:
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Mahsa M Amoli; Wendy Thomson; Ali H Hajeer; Maria C Calviño; Carlos Garcia-Porrua; William E R Ollier; Miguel A Gonzalez-Gay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of rheumatology Volume: 29 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-04 Completed Date: 2003-04-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 2367-70 Citation Subset: IM |
Affiliation:
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ARC Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chemokine CCL5 / genetics Chemokine CXCL5 Chemokines, CXC* Child Child, Preschool DNA Mutational Analysis Female Gene Frequency / genetics Genetic Predisposition to Disease / genetics* Genetic Testing Genotype Humans Interleukin-8 / analogs & derivatives*, genetics* Male Middle Aged Nephritis / etiology*, genetics* Polymorphism, Genetic / genetics* Purpura, Schoenlein-Henoch / complications*, genetics* |
| Chemical | |
Reg. No./Substance:
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0/CXCL5 protein, human; 0/Chemokine CCL5; 0/Chemokine CXCL5; 0/Chemokines, CXC; 0/Interleukin-8 |
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