Document Detail


Interleukin-6, tumour necrosis factor-alpha and insulin relationships to body composition, metabolism and resting energy expenditure in a migrant Asian Indian population.
MedLine Citation:
PMID:  17381487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Systemic inflammation and insulin resistance may play important roles in the pathogenesis of obesity-related diseases for which migrant Asian Indians are at particularly high risk. We examined relationships between markers of insulin resistance and inflammation, resting energy expenditure (REE), and body composition. DESIGN AND METHODS: Measurements were made of total and regional body composition, including regional fat mass (FM) and appendicular skeletal muscle mass (ASMM) by dual-energy X-ray absorptiometry (DXA), REE by indirect calorimetry and fasting interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, glucose and insulin, in 79 healthy Asian Indians (38F, 41M; age 30-49 years) from urban Auckland, New Zealand. Beta-cell function (HOMA B%) and insulin sensitivity (HOMA S%) were derived using homeostatic model assessment. RESULTS: Men had a more central distribution of body fat than women. REE was strongly correlated with IL-6 concentrations in men but not in women. In both sexes, IL-6 was associated positively with percentage body fat and HOMA B% and inversely with ASMM and HOMA S%. Insulin increased and HOMA S% decreased with increasing waist-to-hip ratio and abdominal-to-thigh fat ratio in men but not in women. TNF-alpha was not significantly associated with any of the variables examined. CONCLUSION: Relationships between body fat distribution and HOMA S% were strongly sex dependent and may indicate a greater propensity for development of the metabolic syndrome among male Asian Indians than females in the age group examined.
Authors:
Elaine C Rush; Lindsay D Plank; Chittaranjan S Yajnik
Related Documents :
10526727 - Heterogeneity in associations between macronutrient intake and lipoprotein profile in i...
18666027 - Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical dis...
15004437 - Modulation of cortisol metabolism during treatment of acromegaly is independent of body...
19026257 - A prospective observational study of obesity, body composition, and insulin resistance ...
9023597 - Maximal secretory capacity of somatotrope cells in obesity: comparison with gh deficiency.
3290627 - Control of spontaneous glucose intolerance, hyperinsulinemia, and islet hyperplasia in ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-23
Journal Detail:
Title:  Clinical endocrinology     Volume:  66     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  684-90     Citation Subset:  IM    
Affiliation:
Institute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand. elaine.rush@aut.ac.nz
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adult
Analysis of Variance
Asian Continental Ancestry Group
Biological Markers / blood
Blood Glucose / analysis
Body Composition / physiology*
Calorimetry, Indirect
Energy Metabolism
Female
Humans
India / ethnology
Insulin / blood*
Insulin Resistance
Interleukin-6 / blood*
Male
Middle Aged
New Zealand
Regression Analysis
Sex Factors
Tumor Necrosis Factor-alpha / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The analgesic efficacy of lidocaine/prilocaine (EMLA) cream during fine-needle aspiration biopsy of ...
Next Document:  Detection of RET/PTC, TRK and BRAF mutations in preoperative diagnosis of thyroid nodules with indet...