Document Detail

Interleukin-6, tumour necrosis factor-alpha and insulin relationships to body composition, metabolism and resting energy expenditure in a migrant Asian Indian population.
MedLine Citation:
PMID:  17381487     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Systemic inflammation and insulin resistance may play important roles in the pathogenesis of obesity-related diseases for which migrant Asian Indians are at particularly high risk. We examined relationships between markers of insulin resistance and inflammation, resting energy expenditure (REE), and body composition. DESIGN AND METHODS: Measurements were made of total and regional body composition, including regional fat mass (FM) and appendicular skeletal muscle mass (ASMM) by dual-energy X-ray absorptiometry (DXA), REE by indirect calorimetry and fasting interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, glucose and insulin, in 79 healthy Asian Indians (38F, 41M; age 30-49 years) from urban Auckland, New Zealand. Beta-cell function (HOMA B%) and insulin sensitivity (HOMA S%) were derived using homeostatic model assessment. RESULTS: Men had a more central distribution of body fat than women. REE was strongly correlated with IL-6 concentrations in men but not in women. In both sexes, IL-6 was associated positively with percentage body fat and HOMA B% and inversely with ASMM and HOMA S%. Insulin increased and HOMA S% decreased with increasing waist-to-hip ratio and abdominal-to-thigh fat ratio in men but not in women. TNF-alpha was not significantly associated with any of the variables examined. CONCLUSION: Relationships between body fat distribution and HOMA S% were strongly sex dependent and may indicate a greater propensity for development of the metabolic syndrome among male Asian Indians than females in the age group examined.
Elaine C Rush; Lindsay D Plank; Chittaranjan S Yajnik
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-23
Journal Detail:
Title:  Clinical endocrinology     Volume:  66     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  684-90     Citation Subset:  IM    
Institute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.
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MeSH Terms
Absorptiometry, Photon
Analysis of Variance
Asian Continental Ancestry Group
Biological Markers / blood
Blood Glucose / analysis
Body Composition / physiology*
Calorimetry, Indirect
Energy Metabolism
India / ethnology
Insulin / blood*
Insulin Resistance
Interleukin-6 / blood*
Middle Aged
New Zealand
Regression Analysis
Sex Factors
Tumor Necrosis Factor-alpha / blood*
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 11061-68-0/Insulin

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