Document Detail

Interleukin-6 and tumor necrosis factor alpha in relation to myocardial infarct size and collagen formation.
MedLine Citation:
PMID:  13680554     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) levels increase after acute myocardial infarction (AMI) in humans. Experimental data suggest that these cytokines regulate the initiation of scar formation after AMI. We investigated the interrelationships of IL-6 and TNF-alpha, tissue injury, infarct size, cardiac function, and collagen formation in humans. METHODS: Serum and plasma samples were taken on 93 patients receiving thrombolytic treatment for their first AMI. Collagen formation was evaluated by measuring concentrations of serum aminoterminal propeptide of type III procollagen (PIIINP). RESULTS: IL-6 levels increased by 44% (P<.001) and peaked at 24 hours. Peak IL-6 levels correlated positively with area under the curve of creatine kinase MB mass (r=.31, P<.01), peak troponin T level (r=.34, P<.005), and PIIINP measured at discharge (r=.46, P<.001). There were no changes in TNF-alpha levels, and patients with left ventricular dysfunction (EF<40%) had similar TNF-alpha levels as those with preserved left ventricular function. CONCLUSIONS: IL-6 may regulate collagen formation and thus remodeling of the left ventricle after AMI. In addition, TNF-alpha measurement is useless in the assessment of infarct size or left ventricular function during the immediate post-infarction period.
Mikko Puhakka; Jarkko Magga; Seppo Hietakorpi; Ilkka Penttilä; Paavo Uusimaa; Juha Risteli; Keijo Peuhkurinen
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  9     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-18     Completed Date:  2004-03-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-32     Citation Subset:  IM    
Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Area Under Curve
Arrhythmias, Cardiac / blood,  drug therapy,  physiopathology
Biological Markers / blood
C-Reactive Protein / drug effects,  metabolism
Collagen / blood*,  drug effects
Creatine Kinase / drug effects,  metabolism
Creatine Kinase, MB Form
Enalapril / therapeutic use
Interleukin-6 / blood*
Isoenzymes / drug effects,  metabolism
Myocardial Infarction / blood*,  drug therapy,  physiopathology
Peptide Fragments / blood,  drug effects
Procollagen / blood,  drug effects
Severity of Illness Index
Statistics as Topic
Stroke Volume / drug effects
Tetrahydroisoquinolines / therapeutic use
Time Factors
Treatment Outcome
Trinitrotoluene / blood
Tumor Necrosis Factor-alpha / drug effects,  metabolism*
Ventricular Dysfunction, Left / blood,  drug therapy,  physiopathology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Biological Markers; 0/Interleukin-6; 0/Isoenzymes; 0/Peptide Fragments; 0/Procollagen; 0/Tetrahydroisoquinolines; 0/Tumor Necrosis Factor-alpha; 0/procollagen Type III-N-terminal peptide; 118-96-7/Trinitrotoluene; 75847-73-3/Enalapril; 82586-55-8/quinapril; 9007-34-5/Collagen; 9007-41-4/C-Reactive Protein; EC Kinase; EC Kinase, MB Form

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