Document Detail

Interleukin-6 stimulates lipolysis and fat oxidation in humans.
MedLine Citation:
PMID:  12843134     Owner:  NLM     Status:  MEDLINE    
Although IL-6 is a key modulator of immune function, it also plays a role in regulating substrate metabolism. To determine whether IL-6 affects lipid metabolism, 18 healthy men were infused for 3 h with saline (Con; n = 6) or a high dose (High-rhIL6; n = 6) or a low dose (Low-rhIL6; n = 6) of recombinant human IL-6 (rhIL-6). The IL-6 concentration during Con, Low-rhIL6, and High-rhIL6 was at a steady state after 30 min of infusion at approximately 4, 140, and 320 pg/ml, respectively. Either dose of rhIL-6 was associated with a similar increase in fatty acid (FA) concentration and endogenous FA rate of appearance (R(a)) from 90 min after the start of the infusion. The FA concentration and FA R(a) continued to increase until the cessation of rhIL-6 infusion, reaching levels approximately 50% greater than Con values. The elevated levels reached at the end of rhIL-6 infusion persisted at least 3 h postinfusion. Triacylglycerol concentrations were unchanged during rhIL-6 infusion, whereas whole body fat oxidation increased after the second hour of rhIL-6 infusion. Of note, during Low-rhIL6, the induced elevation in FA concentration and FA R(a) occurred in the absence of any change in adrenaline, insulin, or glucagon, and no adverse side effects were observed. In conclusion, the data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia.
Gerrit van Hall; Adam Steensberg; Massimo Sacchetti; Christian Fischer; Charlotte Keller; Peter Schjerling; Natalie Hiscock; Kirsten Møller; Bengt Saltin; Mark A Febbraio; Bente K Pedersen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  88     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3005-10     Citation Subset:  AIM; IM    
Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark.
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MeSH Terms
Energy Metabolism / drug effects*,  immunology
Epinephrine / blood
Fatty Acids / metabolism*
Glucagon / blood
Glycerol / metabolism
Hydrocortisone / blood
Insulin / blood
Interleukin-6 / administration & dosage*,  metabolism
Lipolysis / drug effects*,  immunology
Norepinephrine / blood
Oxygen Consumption / drug effects,  immunology
Recombinant Proteins / administration & dosage
Triglycerides / metabolism
Reg. No./Substance:
0/Fatty Acids; 0/Interleukin-6; 0/Recombinant Proteins; 0/Triglycerides; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 56-81-5/Glycerol; 9007-92-5/Glucagon
Comment In:
J Clin Endocrinol Metab. 2003 Jul;88(7):3003-4   [PMID:  12843133 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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