| Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. | |
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MedLine Citation:
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PMID: 11731593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Prolonged exercise results in a progressive decline in glycogen content and a concomitant increase in the release of the cytokine interleukin-6 (IL-6) from contracting muscle. This study tests the hypothesis that the exercise-induced IL-6 release from contracting muscle is linked to the intramuscular glycogen availability. 2. Seven men performed 5 h of a two-legged knee-extensor exercise, with one leg with normal, and one leg with reduced, muscle glycogen content. Muscle biopsies were obtained before (pre-ex), immediately after (end-ex) and 3 h into recovery (3 h rec) from exercise in both legs. In addition, catheters were placed in one femoral artery and both femoral veins and blood was sampled from these catheters prior to exercise and at 1 h intervals during exercise and into recovery. 3. Pre-exercise glycogen content was lower in the glycogen-depleted leg compared with the control leg. Intramuscular IL-6 mRNA levels increased with exercise in both legs, but this increase was augmented in the leg having the lowest glycogen content at end-ex. The arterial plasma concentration of IL-6 increased from 0.6 +/- 0.1 ng x l(-1) pre-ex to 21.7 +/- 5.6 ng x l(-1) end-ex. The depleted leg had already released IL-6 after 1 h (4.38 +/- 2.80 ng x min(-1) (P < 0.05)), whereas no significant release was observed in the control leg (0.36 +/- 0.14 ng x min(-1)). A significant net IL-6 release was not observed until 2 h in the control leg. 4. This study demonstrates that glycogen availability is associated with alterations in the rate of IL-6 production and release in contracting skeletal muscle. |
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Authors:
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A Steensberg; M A Febbraio; T Osada; P Schjerling; G van Hall; B Saltin; B K Pedersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of physiology Volume: 537 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-03 Completed Date: 2002-02-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 633-9 Citation Subset: IM |
Affiliation:
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The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Availability Exercise / physiology Glycogen / metabolism* Humans Interleukin-6 / biosynthesis* Knee / physiology Male Muscle Contraction / physiology* Muscle, Skeletal / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 9005-79-2/Glycogen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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