Document Detail


Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content.
MedLine Citation:
PMID:  11731593     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Prolonged exercise results in a progressive decline in glycogen content and a concomitant increase in the release of the cytokine interleukin-6 (IL-6) from contracting muscle. This study tests the hypothesis that the exercise-induced IL-6 release from contracting muscle is linked to the intramuscular glycogen availability. 2. Seven men performed 5 h of a two-legged knee-extensor exercise, with one leg with normal, and one leg with reduced, muscle glycogen content. Muscle biopsies were obtained before (pre-ex), immediately after (end-ex) and 3 h into recovery (3 h rec) from exercise in both legs. In addition, catheters were placed in one femoral artery and both femoral veins and blood was sampled from these catheters prior to exercise and at 1 h intervals during exercise and into recovery. 3. Pre-exercise glycogen content was lower in the glycogen-depleted leg compared with the control leg. Intramuscular IL-6 mRNA levels increased with exercise in both legs, but this increase was augmented in the leg having the lowest glycogen content at end-ex. The arterial plasma concentration of IL-6 increased from 0.6 +/- 0.1 ng x l(-1) pre-ex to 21.7 +/- 5.6 ng x l(-1) end-ex. The depleted leg had already released IL-6 after 1 h (4.38 +/- 2.80 ng x min(-1) (P < 0.05)), whereas no significant release was observed in the control leg (0.36 +/- 0.14 ng x min(-1)). A significant net IL-6 release was not observed until 2 h in the control leg. 4. This study demonstrates that glycogen availability is associated with alterations in the rate of IL-6 production and release in contracting skeletal muscle.
Authors:
A Steensberg; M A Febbraio; T Osada; P Schjerling; G van Hall; B Saltin; B K Pedersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  537     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-03     Completed Date:  2002-02-11     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  633-9     Citation Subset:  IM    
Affiliation:
The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Availability
Exercise / physiology
Glycogen / metabolism*
Humans
Interleukin-6 / biosynthesis*
Knee / physiology
Male
Muscle Contraction / physiology*
Muscle, Skeletal / physiology*
Chemical
Reg. No./Substance:
0/Interleukin-6; 9005-79-2/Glycogen
Comments/Corrections

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