Document Detail


Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legs.
MedLine Citation:
PMID:  15449266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Abdominal aortic aneurysm (AAA) repair is associated with a systemic inflammatory response. This inflammatory response probably arises as a result of an ischaemia-reperfusion injury to the legs and gastrointestinal tract. In this study the relative contributions of these areas to the inflammatory response were assessed during elective AAA repair. METHODS: Blood was sampled from the femoral vein, portal vein and radial artery of 14 patients undergoing elective AAA repair at five time points during the procedure. Plasma was snap-frozen for subsequent batch analysis of interleukin (IL) 6. RESULTS: The plasma IL-6 concentration rose steadily throughout the procedure at all three locations. The increase in plasma IL-6 was significantly greater in the portal vein than in the radial artery during ischaemia (P = 0.020). The plasma IL-6 concentration was also significantly higher in the portal vein than in the femoral vein (P < 0.001) and radial artery (P < 0.001) during reperfusion. There were no significant differences between radial artery and femoral vein IL-6 levels at any time point. CONCLUSION: Ischaemia and reperfusion during AAA repair were associated with a marked increase in IL-6 concentration in the portal vein, suggesting that IL-6 was produced by the gastrointestinal tract.
Authors:
M G A Norwood; M J Bown; A J Sutton; M L Nicholson; R D Sayers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  91     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-27     Completed Date:  2004-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  1153-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2004 British Journal of Surgery Society Ltd.
Affiliation:
Department of Surgery, University of Leicester, Leicester, UK. drmikenorwood@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Aortic Aneurysm, Abdominal / metabolism,  surgery*
Female
Gastrointestinal Tract / blood supply
Humans
Interleukin-6 / metabolism*
Ischemia / etiology
Leg / blood supply
Male
Middle Aged
Portal Vein
Radial Artery
Reperfusion Injury / etiology
Systemic Inflammatory Response Syndrome / etiology,  metabolism
Chemical
Reg. No./Substance:
0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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