Document Detail

Interleukin-6 is a predictor of mortality in stable hemodialysis patients.
MedLine Citation:
PMID:  19690405     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Mortality in end-stage renal disease patients with dialysis remains high. A high percentage of dialysis patients display signs of chronic microinflammation. To clarify whether microinflammation is involved in the high incidence of poor prognosis in dialysis patients, we investigated the association of inflammatory markers with mortality in a prospective observational cohort study. METHODS: 120 patients undergoing hemodialysis were enrolled. Baseline cross-sectional analysis of the relationship between inflammatory markers [interleukin-6 (IL-6), tumor necrosis factor-alpha and high-sensitivity C-reactive protein] and other factors, along with a survival analysis for death, were performed. All subjects were divided into 2 groups according to the median value of IL-6. RESULTS: The mortality rate was significantly higher in the high (20.0%) compared with the low IL-6 group (3.3%, p = 0.0046). Receiver-operating characteristic curves indicated high mortality to be closely associated with a high IL-6 level rather than tumor necrosis factor-alpha. In stepwise multiple regression analyses, age, phosphorus and high-sensitivity C-reactive protein were independent predictors of IL-6 (R(2) = 0.466, p < 0.0001). CONCLUSIONS: These data clearly show that plasma IL-6 is a powerful predictor of all-cause mortality in dialysis patients.
Yukiko Hasuike; Hiroshi Nonoguchi; Katsukiyo Ito; Miki Naka; Rie Kitamura; Masayoshi Nanami; Masanori Tokuyama; Aritoshi Kida; Yoshinaga Otaki; Takahiro Kuragano; Takeshi Nakanishi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-19
Journal Detail:
Title:  American journal of nephrology     Volume:  30     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-02     Completed Date:  2009-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  389-98     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Division of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.
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MeSH Terms
Follow-Up Studies
Interleukin-6 / blood*
Kidney Failure, Chronic / blood*,  mortality*,  therapy
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
ROC Curve
Regression Analysis
Renal Dialysis / mortality*
Risk Factors
Tumor Necrosis Factor-alpha / blood
Reg. No./Substance:
0/IL6 protein, human; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

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