Document Detail

Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis.
MedLine Citation:
PMID:  19946956     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted.
MATERIAL AND METHODS: We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 -174 G/C and -572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 -6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well.
RESULTS AND CONCLUSION: The present meta-analysis indicates that the IL-6 -174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And -572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.
Mei-ying Shao; Ping Huang; Ran Cheng; Tao Hu
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  10     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-03-01     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  920-7     Citation Subset:  IM    
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
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MeSH Terms
Case-Control Studies
Chronic Disease
Gene Frequency
Interleukin-6 / genetics*
Periodontitis / genetics*,  pathology
Polymorphism, Genetic*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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