| Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. | |
| | |
MedLine Citation:
|
PMID: 15220185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mechanisms that mediate the tightly controlled production and clearance of glucose during muscular work are unclear, and it has been suggested that an unidentified "work factor" exists that influences the contraction-induced increase in endogenous glucose production (EGP). The cytokine interleukin (IL)-6 is released from skeletal muscle during contraction. Here we show that IL-6 contributes to the contraction-induced increase in EGP. Six men performed 2 h of bicycle exercise on three separate occasions, at a relatively high intensity (HI) or at a low intensity with (LO + IL-6) or without (LO) an infusion of recombinant human IL-6 that matched the circulating concentration of IL-6 seen in HI exercise. The stable isotope 6,6 (2)H(2) glucose was infused to calculate EGP (rate of glucose appearance [R(a)]), whole-body glucose disposal (rate of glucose disappearance [R(d)]), and metabolic clearance rate (MCR) of glucose. Glucose R(a), R(d), and MCR were higher (P < 0.05) at HI than at LO. Throughout exercise at LO + IL-6, glucose R(a) and R(d) were higher (P < 0.05) than LO, even though the exercise intensity was identical. In addition, MCR was higher (P < 0.05) at LO + IL-6 than at LO at 90 min. Insulin, glucagon, epinephrine, norepinephrine, cortisol, and growth hormone were identical when comparing LO + IL-6 with LO. These data suggest that IL-6 influences glucose homeostasis during exercise. Our results provide potential new insights into factors that mediate glucose production and disposal and implicates IL-6 in the so-called "work factor." |
| | |
Authors:
|
Mark A Febbraio; Natalie Hiscock; Massimo Sacchetti; Christian P Fischer; Bente K Pedersen |
Related Documents
:
|
6846535 - Effect of endurance training on glucose kinetics during exercise. 9458525 - Exercise in the management of non-insulin-dependent diabetes mellitus. 2022575 - Carbohydrate metabolism during intense exercise when hyperglycemic. 18171435 - Exercise training-induced improvements in insulin action. 1174005 - Circulatory and respiratory effects evoked by hypertonic ventriculo-cisternal perfusion. 2100355 - Acute emotional and cardiovascular effects of stressful mental work during aerobic exer... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Diabetes Volume: 53 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 2004 Jul |
Date Detail:
|
Created Date: 2004-06-28 Completed Date: 2004-09-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
|
Languages: eng Pagination: 1643-8 Citation Subset: AIM; IM |
Affiliation:
|
Skeletal Muscle Research Laboratory, Center for Nutrition, Metabolism and Endocrinology, RMIT University, P.O. Box 71, Bundoora 3083, Victoria, Australia. mark.febbraio@rmit.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Bicycling Exercise / physiology Fatty Acids, Nonesterified / blood Glucose / biosynthesis, metabolism* Homeostasis / physiology* Hormones / blood Humans Interleukin-6 / pharmacology, physiology* Lactic Acid / blood Male Metabolic Clearance Rate Muscle Contraction / physiology* Muscle, Skeletal / physiology* Recombinant Proteins / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Nonesterified; 0/Hormones; 0/Interleukin-6; 0/Recombinant Proteins; 50-21-5/Lactic Acid; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic.
Next Document: AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake...