| Interleukin-6 levels are not increased in women with postpartum thyroid dysfunction. | |
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MedLine Citation:
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PMID: 9623726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postpartum thyroid dysfunction (PPTD) is an autoimmune-mediated thyroid destructive process. Human interleukin-6 (IL-6) is a cytokine found to be increased in subacute thyroiditis, amiodarone-induced thyrotoxicosis, Graves' disease, and other thyroid destructive processes. We report serum IL-6 levels in PPTD in two independent studies. New York Study: In a previous prospective study we demonstrated that PPTD occurred in 25% (7/28) of women with type 1 diabetes mellitus. IL-6 determinations were made on the frozen serum samples of these 28 women during each trimester of their pregnancy and at 1.5, 3, 6, 9, and 12 months postpartum. IL-6 levels were found to be similar in women with PPTD compared with women without PPTD (mean 3.06+/-2.25 vs. 2.51+/-2.21 pg/mL; p = 0.15). No difference in IL-6 levels was found between the pre- and the postpartum periods (mean 2.67+/-1.82 vs. 3.04+/-2.44 pg/mL; p = 0.30) in all 28 women. Cardiff Study: Serum IL-6 levels were measured on frozen serum samples of 30 women with PPTD. IL-6 levels were below the detection limit (25 fmol/L or 0.65 pg/mL) in 94 (67%) of these samples. No significant difference in the mean serum IL-6 levels were found between any time points in the study. There was no correlation between serum IL-6 levels, thyroid peroxidase (TPO)- antibodies and serum thyrotropin (TSH) levels at any time point. IL-6 levels during pregnancy or postpartum were not found to be significantly different in women with PPTD compared with women without PPTD. |
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Authors:
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L Ahmad; A Parkes; J Lazarus; L Bartalena; E Martino; E Diamond; A Stagnaro-Green |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 8 ISSN: 1050-7256 ISO Abbreviation: Thyroid Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-08-18 Completed Date: 1998-08-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 371-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies / analysis Diabetes Mellitus, Type 1 / blood Female Humans Hyperthyroidism / blood* Hypothyroidism / blood* Interleukin-6 / blood* Iodide Peroxidase / immunology Postpartum Period / immunology Pregnancy Prospective Studies Puerperal Disorders / blood* Retrospective Studies Thyrotropin / blood |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Interleukin-6; 9002-71-5/Thyrotropin; EC 1.11.1.8/Iodide Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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