| Interleukin-6 and its considerable role in the pathogenesis of thyrotoxicosis-related disturbances of bone turnover in postmenopausal women. | |
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MedLine Citation:
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PMID: 21879468 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Thyrotoxicosis is more frequent in postmenopausal women than in the general population, effectively accelerating bone turnover. Interleukin-6 has been shown to be involved in the pathogenesis of bone disorders. Thus, the aim of the present study was to assess the role of IL-6 and its soluble receptor in the pathogenesis of thyrotoxicosis-related disturbances of bone turnover in oestrogen-deficient women. Material and methods: The study was carried out in 40 subjects with toxic nodular goitre in three groups: Group 1 - 13 premenopausal females, mean age 36 ± 15 years (PremTx→PremEu); Group 2 - 12 postmenopausal females, mean age 66 ± 14 years (PostTx→PostEu); and Group 3 - 15 males, mean age 45 ± 21 years (MTx→MEu). Overt thyrotoxicosis and euthyreosis after treatment with thyrostatics were confirmed by thyrotropin, free thyroxine and free triiodothyronin concentrations. Serum levels of bone turnover markers: TRACP5b and osteocalcin as well as serum IL-6 and IL-6sR were determined using ELISA kits. Results: TRACP5b/osteocalcin quotient was significantly elevated in the PostTx females compared to the PremTx women (p 〈 0.02). There was a positive correlation between serum TRACP5b and osteocalcin in the studied patients (R = 0.45, p 〈 0.001). Levels of serum IL-6 values were significantly elevated in PostTx: 3.0 (2.14-6.40) and MTx: 2.24 (1.60-5.10), compared to PremTx females: 1.39 (0.96-2.14) (p 〈 0.01 and p 〈 0.05 respectively). There were significant positive correlations between IL-6 and IL-6sR concentrations (R = 0.22, p 〈 0.05) and between IL-6sR and TRACP5b serum levels (R = 0.23, p 〈 0.05). Conclusions: The results of our study suggest that interleukin-6 plays a considerable role in the pathogenesis of thyrotoxicosis-related disturbances of bone turnover in oestrogen-deficient women. (Pol J Endocrinol 2011; 62 (4): 299-302). |
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Authors:
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Janusz Mysliwiec; Malgorzata Adamczyk; Agnieszka Nikolajuk; Maria Gorska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endokrynologia Polska Volume: 62 ISSN: 0423-104X ISO Abbreviation: Endokrynol Pol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370674 Medline TA: Endokrynol Pol Country: Poland |
Other Details:
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Languages: eng Pagination: 299-302 Citation Subset: IM |
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