Document Detail


Interleukin-6 and interleukin-8 in cervical and amniotic fluid: relationship to microbial invasion of the chorioamniotic membranes.
MedLine Citation:
PMID:  15924526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the levels of interleukin (IL)-6 and IL-8 in cervical and amniotic fluid in relation to the presence of bacteria in the membranes in women in preterm labour (PTL). DESIGN: A prospective follow up study. SETTING: Sahlgrenska University Hospital, Göteborg, Sweden. Sample Women with singleton pregnancies (<34 weeks) presenting with PTL (n = 30). METHODS: Amniotic fluid was retrieved transabdominally and cervical fluid was sampled from the uterine cervix at admission and analysed for IL-6 and IL-8 with enzyme-linked immunosorbent assay (ELISA). At birth, the chorioamniotic membranes were separated and samples for polymerase chain reaction (PCR) for Ureaplasma urealyticum and Mycoplasma hominis and general culture were obtained. MAIN OUTCOME MEASURE: IL-6 and IL-8 in relation to microbial invasion of the chorioamniotic membranes. RESULTS: Bacteria were found in the membranes in 8 of 21 patients in PTL for whom chorioamnion as well as amniotic fluid PCR and cultures were available. Cervical IL-6 was associated with detectable bacteria in the chorioamniotic membranes in women in PTL (median 8.2 ng/mL vs 0.73 ng/mL; P = 0.01). The IL-6 (median 13 ng/mL vs 1.7 ng/mL; P = 0.004) and IL-8 (median 7.2 ng/mL vs 0.28 ng/mL; P = 0.01) levels in amniotic fluid were higher in PTL cases in which bacteria were found in the chorioamniotic membranes. CONCLUSION: IL-6 in cervical fluid and IL-6 and IL-8 in amniotic fluid were higher in those PTL cases in which bacteria were found in the chorioamniotic membranes.
Authors:
Bo Jacobsson; Inger Mattsby-Baltzer; Henrik Hagberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  112     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-31     Completed Date:  2005-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  719-24     Citation Subset:  AIM; IM    
Affiliation:
Perinatal Center, Department of Obstetrics and Gynaecology, Institute for the Health of Women and Children, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amnion / microbiology
Amniotic Fluid / metabolism*
Cervix Uteri / metabolism*,  microbiology
Chorion / microbiology
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Interleukin-6 / metabolism*
Interleukin-8 / metabolism*
Mycoplasma Infections / diagnosis
Mycoplasma hominis / isolation & purification
Obstetric Labor, Premature / metabolism,  microbiology*
Pregnancy
Pregnancy Complications, Infectious / diagnosis*,  metabolism
Prospective Studies
Ureaplasma Infections / diagnosis
Ureaplasma urealyticum / isolation & purification
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/Interleukin-8

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