| Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications. | |
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MedLine Citation:
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PMID: 21464062 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention. |
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Authors:
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Randeep S Jawa; Sergio Anillo; Kristin Huntoon; Heinz Baumann; Mahmoud Kulaylat |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of intensive care medicine Volume: 26 ISSN: 1525-1489 ISO Abbreviation: J Intensive Care Med Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-04-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610344 Medline TA: J Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 73-87 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. rjawa@unmc.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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