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Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications.
MedLine Citation:
PMID:  21464062     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.
Authors:
Randeep S Jawa; Sergio Anillo; Kristin Huntoon; Heinz Baumann; Mahmoud Kulaylat
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  26     ISSN:  1525-1489     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-87     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. rjawa@unmc.edu.
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