| Interleukin-6: A growth factor stimulating collagen synthesis in human tendon. | |
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MedLine Citation:
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PMID: 21350025 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Human connective tissue e.g. tendons responds dynamically to physical activity, with collagen synthesis being increased after both acute and prolonged exercise or training. Markers of collagen synthesis and degradation as well as concentration of several potential growth factors have been shown to increase markedly in the peritendinous tissue around the human Achilles tendon following exercise with Interleukin-6 (IL-6) showing the largest fold increase suggesting that IL-6 may be involved in transforming mechanical loading into collagen synthesis in human tendon tissue. In the present study the tissue levels of type I collagen turnover markers (procollagen type I N-terminal propeptid (PINP) and C-terminal telopeptid of type I collagen (ICTP)) were measured by the use of microdialysis in peritendinous tissue of the Achilles tendon in 14 male volunteers, who had recombinant human IL-6 infused into the peritendinous tissue of the Achilles' tendon in one leg, with the other leg serving as control. Subjects were randomly assigned to either a resting group or an exercise group performing a 1-hour treadmill run (12km/h, 2% uphill) prior to infusion. In addition serum concentrations of IL-6, PINP, ICTP and ICTX were obtained. The peritendinous concentrations of PINP rose markedly in response to rhIL-6 infusion in both the exercise and the rest group demonstrating that infusion of IL-6 significant stimulates collagen synthesis in the peritendinous tissue in humans. This indicates that changes in the local concentration of IL-6 in peritendinous tissue are important for collagen synthesis and supports the hypothesis that IL-6 is an important growth factor of the connective tissue in healthy human tendons. |
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Authors:
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Mette Bisgaard Andersen; Jessica Pingel; Michael Kjaer; Henning Langberg |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-24 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Sports Medicine Research Unit. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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