Document Detail


Interleukin-6 and granulocyte-macrophage colony-stimulating factor in apical periodontitis: correlation with clinical and histologic findings of the involved teeth.
MedLine Citation:
PMID:  12588453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apical periodontitis is characterized by the presence of immunocompetent cells producing a wide variety of inflammatory mediators. Releasing cytokines with long-range action, such as interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF), apical periodontitis may induce changes in remote organs of the host. This study quantified the levels of IL-6 and GM-CSF in symptomatic and asymptomatic human periradicular lesions. Lesions were also characterized by size and histologic findings. Tissue samples were homogenized and supernatants were assayed using an enzyme-linked immunosorbent assay (ELISA). Correlations between cytokine levels and characteristic features (as single variables) of the lesions were analysed. There was a trend for higher levels of IL-6 and GM-CSF in symptomatic than in asymptomatic lesions, but the difference was not significant. Levels also tended to be higher in large than in small lesions, in polymorphonuclear (PMN) cell-rich than in PMN cell-poor samples, and in epithelialized than in non-epithelialized lesions. Significantly higher levels of IL-6 (778.1 +/- 220.5 pg/microg) and GM-CSF (363.3 +/- 98.4 pg/microg) were found in samples coincidentally possessing symptomatic and epithelialized features than in asymptomatic, small, PMN cell-poor, non-epithelialized lesions (IL-6: 45.2 +/- 13.1 pg/microg and GM-CSF: 135.1 +/- 26.4 pg/microg). These results suggest that symptomatic lesions containing epithelial cells represent an immunologically active stage of apical periodontitis, whereas asymptomatic, small, PMN cell-poor, non-epithelialized lesions represent healing apical lesions.
Authors:
T Radics; C Kiss; I Tar; I J Márton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oral microbiology and immunology     Volume:  18     ISSN:  0902-0055     ISO Abbreviation:  Oral Microbiol. Immunol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-17     Completed Date:  2003-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707451     Medline TA:  Oral Microbiol Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  D    
Affiliation:
Department of Restorative Dentistry, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Enzyme-Linked Immunosorbent Assay
Female
Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis*
Humans
Interleukin-6 / biosynthesis*
Male
Middle Aged
Neutrophils / metabolism
Periapical Periodontitis / immunology*
Statistics, Nonparametric
Wound Healing / immunology
Chemical
Reg. No./Substance:
0/Interleukin-6; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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