Document Detail

Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblasts.
MedLine Citation:
PMID:  2166509     Owner:  NLM     Status:  MEDLINE    
We have investigated the effect of interleukin 6 (IL-6) on the synthesis of tissue inhibitor of metalloproteinases (TIMP) and matrix metalloproteinases (MMPs), collagenase (MMP-1) and stromelysin (MMP-3) using human skin and uterine cervical fibroblasts. IL-6 did not modulate the expression of MMPs by these fibroblasts, but the production of TIMP was enhanced by IL-6 in a dose dependent manner, whereas IL-1 stimulated the production of both MMPs and TIMP. The combination of IL-6 and IL-1 further augmented IL-1-induced MMPs and TIMP production. The results provide the first evidence that IL-6 participates in the catabolism of the extracellular matrix components by modulating the effects of IL-1 on MMPs and TIMP synthesis as well as its direct effects on the synthesis of TIMP by connective tissue cells.
T Sato; A Ito; Y Mori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  170     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-09-10     Completed Date:  1990-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  824-9     Citation Subset:  IM    
Department of Biochemistry, Tokyo College of Pharmacy, Japan.
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MeSH Terms
Cells, Cultured
Dose-Response Relationship, Drug
Enzyme Precursors / biosynthesis
Extracellular Matrix / drug effects,  enzymology*
Fibroblasts / drug effects,  enzymology*
Glycoproteins / pharmacology
Interleukin-1 / administration & dosage,  pharmacology
Interleukin-6 / administration & dosage,  pharmacology*
Metalloendopeptidases / biosynthesis*
Microbial Collagenase / biosynthesis
Recombinant Proteins / pharmacology
Tissue Inhibitor of Metalloproteinases
Reg. No./Substance:
0/Enzyme Precursors; 0/Glycoproteins; 0/Interleukin-1; 0/Interleukin-6; 0/Recombinant Proteins; 0/Tissue Inhibitor of Metalloproteinases; EC 3.4.24.-/Collagenases; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.-/procollagenase; EC Collagenase

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