Document Detail

Interleukin-6: a cytokine and/or a major modulator of the response to somatic stress.
MedLine Citation:
PMID:  17192581     Owner:  NLM     Status:  MEDLINE    
The hypothalamic-pituitary-adrenal (HPA) axis and the proinflammatory cytokines (and interleukin-6 [IL-6] in particular) are enmeshed in the response to somatic stress, either in health or in acute or chronic disease. Usually IL-6 is elevated in states of septic (such as sepsis) or aseptic inflammation (such as rheumatoid arthritis). Exercise is a form of somatic stress. Local tissue IL-6 elevation is noted during shorter and less intense exercise, whereas brief peripheral IL-6 "bursts" are observed with longer and more intense exercise. Therapeutic interventions that target IL-6 or its soluble receptor are currently assessed, with an emphasis on autoimmune diseases and inflammatory conditions.
George Mastorakos; Ioannis Ilias
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1088     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-28     Completed Date:  2007-03-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-81     Citation Subset:  IM    
Second Department of Obstetrics and Gynecology, University of Athens, Greece.
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MeSH Terms
Inflammation / physiopathology*
Interleukin-6 / immunology*
Neuroimmunomodulation / immunology*
Neurosecretory Systems / immunology
Stress, Physiological / immunology*,  physiopathology*
Reg. No./Substance:

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