| Interleukin-6: a cytokine and/or a major modulator of the response to somatic stress. | |
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MedLine Citation:
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PMID: 17192581 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothalamic-pituitary-adrenal (HPA) axis and the proinflammatory cytokines (and interleukin-6 [IL-6] in particular) are enmeshed in the response to somatic stress, either in health or in acute or chronic disease. Usually IL-6 is elevated in states of septic (such as sepsis) or aseptic inflammation (such as rheumatoid arthritis). Exercise is a form of somatic stress. Local tissue IL-6 elevation is noted during shorter and less intense exercise, whereas brief peripheral IL-6 "bursts" are observed with longer and more intense exercise. Therapeutic interventions that target IL-6 or its soluble receptor are currently assessed, with an emphasis on autoimmune diseases and inflammatory conditions. |
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Authors:
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George Mastorakos; Ioannis Ilias |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1088 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-12-28 Completed Date: 2007-03-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 373-81 Citation Subset: IM |
Affiliation:
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Second Department of Obstetrics and Gynecology, University of Athens, Greece. mastorak@mail.kapatel.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Inflammation / physiopathology* Interleukin-6 / immunology* Neuroimmunomodulation / immunology* Neurosecretory Systems / immunology Stress, Physiological / immunology*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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