Document Detail

Interleukin-6 and cardiovascular diseases.
MedLine Citation:
PMID:  15090695     Owner:  NLM     Status:  MEDLINE    
Inflammatory cytokines are important for both cardiovascular scientists and practicing clinicians. Interleukin-6 (IL-6) has been emphasized by reports of elevated circulating as well as intracardiac IL-6 levels in patients with congestive heart failure (CHF). IL-6 may contribute to the progression of myocardial damage and dysfunction in chronic heart failure syndrome resulting from different causes. As the cause of CHF in cardiomyopathy, myocarditis, allograft rejection, and left ventricular assist device (LVADs) conditions, circulating IL-6 levels are associated with the severity of left ventricular dysfunction, and are also strong predictors of subsequent clinical outcomes. Continuous and excessive production of IL-6 promotes myocardial injury by breaking down both cytokine networks and viral clearance under viral myocarditis. Although IL-6 is likely important in the process of viral antigen presentation, early activation of immune responses and attenuation of viral replication also appear to be significant in an animal model of viral myocarditis. IL-6 can cause cardiac hypertrophy through the IL-6 signal transducing receptor component, glycoprotein 130. There are several interesting cases of cardiac myxoma complicated with mediastinal lymphadenopathy or left ventricular hypertrophy. Increased expression of IL-6 is observed in the myocardium of all donor hearts showing marked dysfunction. Myocardial IL-6 concentrations are also significantly higher in LVAD candidates compared with advanced heart failure patients. Although the IL-6 family plays a central role in the pathophysiology of cardiovascular diseases, it remains to be determined whether the IL-6 family is beneficial or detrimental. Future study will be needed to resolve this question.
Tsugiyasu Kanda; Takashi Takahashi
Related Documents :
23880025 - Evaluation of transcranial sonographic findings and mibg cardiac scintigraphy in the di...
8281545 - Acute myocardial infarction and left ventricular aneurysm in a patient with normal coro...
10814925 - Analysis of the distribution of histologic myocardial lesions during acute cardiac reje...
9209945 - Acute staphylococcal myocarditis masquerading as an acute myocardial infarction.
22115655 - Contemporary clinical applications of coronary intravascular ultrasound.
19644065 - Lesion patterns and stroke mechanisms in concurrent atherosclerosis of intracranial and...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Japanese heart journal     Volume:  45     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-06-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  183-93     Citation Subset:  IM    
Department of General Medicine, Kanazawa Medical University, Ishikawa, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
C-Reactive Protein / metabolism
Cardiomegaly / metabolism
Cardiomyopathies / metabolism
Cardiovascular Diseases / etiology,  metabolism*
Coronary Disease / metabolism
Heart Failure / metabolism*
Heart Transplantation
Interleukin-6 / chemistry,  metabolism*,  physiology*
Myocarditis / metabolism
Myocardium / metabolism*
Tumor Necrosis Factor-alpha / metabolism
Ventricular Dysfunction, Left / metabolism
Reg. No./Substance:
0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A chronological decrease in type A behavior patterns among Japanese male workers in 1995-1999.
Next Document:  Usefulness of simultaneous evaluations of contractile reserve, perfusion, and metabolism during dobu...