Document Detail

Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  21037957     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is one of the main late complications of sulfur mustard poisoning. The aim of this study was to evaluate serum levels of interleukin (IL)-6 in war veterans with pulmonary complications of sulfur mustard poisoning and their correlation with severity of airways disease.
METHODS: Fifty consecutive patients with sulfur mustard poisoning and stable COPD, and of mean age 46.3 ± 9.18 years were enrolled in this study. Thirty healthy men were selected as controls and matched to cases by age and body mass index. Spirometry, arterial blood gas, six- minute walk test, BODE (body mass index, obstruction, dyspnea, and exercise capacity), and St George's Respiratory Questionnaire about quality of life were evaluated. Serum IL-6 was measured in both patient and control groups.
RESULTS: Fifty-four percent of patients had moderate COPD. Mean serum IL-6 levels were 15.01 ± standard deviation (SD) 0.61 pg/dL and 4.59 ± 3.40 pg/dL in the case and control groups, respectively (P = 0.03). There was a significant correlation between IL-6 levels and Global Initiative for Chronic Obstructive Lung Disease stage (r = 0.25, P = 0.04) and between IL-6 and BODE index (r = 0.38, P = 0.01). There was also a significant negative correlation between serum IL-6 and forced expiratory volume in one second (FEV(1), r = -0.36, P = 0.016).
CONCLUSION: Our findings suggest that serum IL-6 is increased in patients with sulfur mustard poisoning and COPD, and may have a direct association with airflow limitation.
Davood Attaran; Shahrzad M Lari; Mohammad Towhidi; Hassan Ghobadi Marallu; Hossein Ayatollahi; Mohammad Khajehdaluee; Mostafa Ghanei; Reza Basiri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-05
Journal Detail:
Title:  International journal of chronic obstructive pulmonary disease     Volume:  5     ISSN:  1178-2005     ISO Abbreviation:  Int J Chron Obstruct Pulmon Dis     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-01     Completed Date:  2011-02-15     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101273481     Medline TA:  Int J Chron Obstruct Pulmon Dis     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  335-40     Citation Subset:  IM    
Lung Disease and Tuberculosis Research Center, Mashhad University of Medical Science, Tehran, Iran.
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MeSH Terms
Body Mass Index
Case-Control Studies
Chemical Warfare Agents / poisoning*
Cross-Sectional Studies
Dyspnea / etiology
Exercise Test
Exercise Tolerance
Forced Expiratory Volume
Inflammation Mediators / blood*
Interleukin-6 / blood*
Lung / physiopathology*
Middle Aged
Mustard Gas / poisoning*
Pulmonary Disease, Chronic Obstructive / chemically induced*,  immunology,  physiopathology
Quality of Life
Severity of Illness Index
Vital Capacity
Reg. No./Substance:
0/Chemical Warfare Agents; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 505-60-2/Mustard Gas

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