| Interleukin 6 Receptor Blockade in Patients With Neuromyelitis Optica Nonresponsive to Anti-CD20 Therapy. | |
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MedLine Citation:
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PMID: 23358868 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE To report first experiences with interleukin 6 receptor inhibition in therapy-resistant neuromyelitis optica (NMO). DESIGN Retrospective case series. SETTING Neurology department at a tertiary referral center. PATIENTS Patients with an aggressive course of NMO switched to tocilizumab after failure of anti-CD20 therapy. MAIN OUTCOME MEASURES Annualized relapse rate and disability progression measured by the Expanded Disability Status Scale. RESULTS We report 3 female patients with a median age of 39 years (range, 26-40 years) and aquaporin 4-positive NMO. All patients had been treated with different immunosuppressive and immunomodulating agents, followed by 1 to 3 cycles of rituximab. Despite complete CD20-cell depletion during rituximab therapy, the median annualized relapse rate was 3.0 (range, 2.3-3.0) and the median Expanded Disability Status Scale score increased from 5.0 (range, 4.5-7.0) to 6.5 (range, 5.0-7.0). After the switch to tocilizumab (median duration of therapy, 18 months), the median annualized relapse rate decreased to 0.6 (range, 0-1.3). A total of 2 relapses occurred; however, they were mild and there were no changes in clinical disability. CONCLUSIONS Interleukin 6 receptor-blocking therapy can be effective in therapy-resistant cases of NMO. Larger controlled studies are needed to confirm the efficacy of tocilizumab. |
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Authors:
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Ilya Ayzenberg; Ingo Kleiter; Alexandra Schröder; Kerstin Hellwig; Andrew Chan; Takashi Yamamura; Ralf Gold |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
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Title: JAMA neurology Volume: - ISSN: 2168-6157 ISO Abbreviation: JAMA Neurol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101589536 Medline TA: JAMA Neurol Country: - |
Other Details:
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Languages: ENG Pagination: 1-4 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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