| Interleukin-6 levels in tension headache patients. | |
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MedLine Citation:
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PMID: 20664340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Cytokines are pain mediators in neurovascular inflammation. This study examined interleukin 6 (IL-6) levels in the serum of tension-type headache (TTH) patients, to determine if inflammation plays a role in the pathogenesis of this condition. METHODS: Serum IL-6 levels were studied in 42 patients and 37 healthy controls from the same region. Of the patients, 20 (47.6%) experiencing TTH less than 15 days per month were placed in episodic tension-type headache (ETTH) group, and 22 (52.3%) with TTH more than 15 days per month were placed in chronic tension-type headache (CTTH) group. RESULTS: The IL-6 level was significantly higher in the patients than in the controls. The IL-6 level of CTTH patients was higher than the controls (P<0.01). The IL-6 level was similar between ETTH and CTTH patients. Correlation analysis revealed a positive relationship only between age and IL-6 level in the patients. CONCLUSIONS: CTTH and ETTH patients had an elevated serum IL-6 level compared with controls. Therefore, we believe that IL-6 may be involved in pain induction or inflammatory mechanisms in TTH. Furthermore studies of the possible connection between chronicity of headaches and cytokine levels are needed. |
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Authors:
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Abdulkadir Koçer; Emel Koçer; Ramazan Memişoğullari; Füsun M Domaç; Hatice Yüksel |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Clinical journal of pain Volume: 26 ISSN: 1536-5409 ISO Abbreviation: Clin J Pain Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8507389 Medline TA: Clin J Pain Country: United States |
Other Details:
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Languages: eng Pagination: 690-3 Citation Subset: IM |
Affiliation:
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Department of Neurology, Düzce University Medical Faculty, Turkey. abdulkadirkocer@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Enzyme-Linked Immunosorbent Assay / methods Female Humans Interleukin-6 / blood* Male Middle Aged Tension-Type Headache / blood*, immunology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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