Document Detail

Interleukin-6 levels in tension headache patients.
MedLine Citation:
PMID:  20664340     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Cytokines are pain mediators in neurovascular inflammation. This study examined interleukin 6 (IL-6) levels in the serum of tension-type headache (TTH) patients, to determine if inflammation plays a role in the pathogenesis of this condition.
METHODS: Serum IL-6 levels were studied in 42 patients and 37 healthy controls from the same region. Of the patients, 20 (47.6%) experiencing TTH less than 15 days per month were placed in episodic tension-type headache (ETTH) group, and 22 (52.3%) with TTH more than 15 days per month were placed in chronic tension-type headache (CTTH) group.
RESULTS: The IL-6 level was significantly higher in the patients than in the controls. The IL-6 level of CTTH patients was higher than the controls (P<0.01). The IL-6 level was similar between ETTH and CTTH patients. Correlation analysis revealed a positive relationship only between age and IL-6 level in the patients.
CONCLUSIONS: CTTH and ETTH patients had an elevated serum IL-6 level compared with controls. Therefore, we believe that IL-6 may be involved in pain induction or inflammatory mechanisms in TTH. Furthermore studies of the possible connection between chronicity of headaches and cytokine levels are needed.
Abdulkadir Koçer; Emel Koçer; Ramazan Memişoğullari; Füsun M Domaç; Hatice Yüksel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Clinical journal of pain     Volume:  26     ISSN:  1536-5409     ISO Abbreviation:  Clin J Pain     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507389     Medline TA:  Clin J Pain     Country:  United States    
Other Details:
Languages:  eng     Pagination:  690-3     Citation Subset:  IM    
Department of Neurology, Düzce University Medical Faculty, Turkey.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay / methods
Interleukin-6 / blood*
Middle Aged
Tension-Type Headache / blood*,  immunology
Young Adult
Reg. No./Substance:

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