| Interleukin-6 (IL-6) -174 G/C polymorphism in familial Mediterranean fever patients with and without amyloidosis. | |
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MedLine Citation:
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PMID: 16299685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Familial Mediterranean fever (FMF) is a recessive disorder characterized by attacks of fever and inflammation. A sustained inflammatory reaction is observed in the disease course, and cytokine levels such as interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha (TNF-alfa) are shown to increase during and between the attacks. In this study, we investigated the role of the functionally important IL-6 -174 G/C polymorphism in the clinical outcome of FMF and amyloidosis. One hundred and fifty-six FMF patients (80 with amyloidosis) and 90 healthy controls were studied. The genotype distributions and allele frequencies of the patients and the controls were found to be similar, and the differences between the groups were not statistically significant. The results show that IL-6 -174 G/C polymorphism is not associated with FMF and amyloidosis. The increase observed in cytokine levels during and between the attacks is more likely due to the inflammatory nature of the disease. |
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Authors:
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Zeynep C Karahan; Aysenur Ozturk; Ece Akar; Nejat Akar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nephrology Volume: 18 ISSN: 1121-8428 ISO Abbreviation: J. Nephrol. Publication Date: 2005 Sep-Oct |
Date Detail:
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Created Date: 2005-11-21 Completed Date: 2006-01-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: Italy |
Other Details:
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Languages: eng Pagination: 582-4 Citation Subset: IM |
Affiliation:
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Pediatric Molecular Genetics Department, Ankara University, School of Medicine, Ankara--Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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etiology,
genetics Familial Mediterranean Fever / complications, genetics* Gene Frequency Genotype Humans Interleukin-6 / genetics* Polymorphism, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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