| Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting. | |
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MedLine Citation:
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PMID: 17374948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is well known that nutritional habits, sleeping patterns and meal frequency have profound effects on maintaining human health. Ramadan is a religious month for Islam, during which Muslims do not eat and drink during the daylight hours. The duration of restricted food and beverage intake is approximately 12 h/day for 1 month, which makes Ramadan a model of prolonged intermittent fasting. METHODS: In order to evaluate the effects of long-lasting modifications of food intake on inflammatory markers and biochemical parameters 40 healthy volunteers of normal weight [20 females aged between 20 and 38 years, 20 males aged between 23 and 39 years, body mass index (BMI) <25 kg/m(2)] who fasted during Ramadan and another 28 healthy age- and BMI-matched volunteers (14 males, 14 females) who did not fast participated in the study. Venous blood samples were taken 1 week before Ramadan, during the last week of Ramadan and 3 weeks after Ramadan. Serum interleukin-6 (IL-6), C-reactive protein (CRP), homocysteine, vitamin B(12), folate, total cholesterol (TC), triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. RESULTS: No significant changes were observed in serum total cholesterol, triglycerides and LDL levels. TC/HDL ratio (HDL risk factor) was decreased during and after Ramadan in both genders in the fasting group while there were no changes in the nonfasting group. IL-6 (p < 0.001), CRP (p < 0.001) and homocysteine (p < 0.01) levels were significantly low during Ramadan in the fasting subjects of both genders when compared to basal values (1 week before Ramadan). CONCLUSION: Our results demonstrate that prolonged intermittent fasting in a model like Ramadan has some positive effects on the inflammatory status of the body and on the risk factors for cardiovascular diseases such as homocysteine, CRP and TC/HDL ratio. |
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Authors:
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Fehime B Aksungar; Aynur E Topkaya; Mahmut Akyildiz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-19 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 51 ISSN: 1421-9697 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-23 Completed Date: 2007-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 88-95 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Biochemistry, Maltepe University, School of Medicine, Istanbul, Turkey. fehimebenli@gmail.com <fehimebenli@gmail.com> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood C-Reactive Protein / analysis* Fasting / blood* Female Homocysteine / blood Humans Interleukin-6 / blood* Lipids / blood Male Vitamin B Complex / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-6; 0/Lipids; 12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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