Document Detail

Interleukin-6⁻¹⁷⁴ and tumor necrosis factor α⁻³⁰⁸ polymorphisms enhance cytokine production by human macrophages exposed to respiratory viruses.
MedLine Citation:
PMID:  20973681     Owner:  NLM     Status:  MEDLINE    
Interleukin-6⁻¹⁷⁴ (IL-6⁻¹⁷⁴) and tumor necrosis factor α⁻³⁰⁸ (TNFα⁻³⁰⁸) are high-cytokine-producing genotypes that are known to increase the susceptibility to infectious diseases, but their influence on cytokine production induced by respiratory viruses is unknown. We exposed human monocyte-derived macrophages from IL-6⁻¹⁷⁴, TNFα⁻³⁰⁸, and normal genotype donors to different respiratory viruses. Respiratory syncytial virus (RSV) stimulation was associated with higher IL-6 concentrations in IL-6⁻¹⁷⁴ donors than in normal donors (P = 0.015); 2 of 7 (29%) polymorphic donors were poor responders compared with 6 of 7 (86%) normal donors (P = 0.002). Adenovirus, influenza virus, and RSV stimulations were associated with higher TNFα concentrations in TNFα⁻³⁰⁸ donors than in normal donors (P = 0.03, <0.01, <0.01). A similar trend was seen with rhinovirus stimulation, but this was not significant. These results show that IL-6⁻¹⁷⁴ and TNFα⁻³⁰⁸ gene polymorphisms lead to enhanced production of the respective cytokines when exposed to specific respiratory viruses. This, in turn, may influence the susceptibility to, severity of, and recovery from respiratory virus infections, or influence the immune response to and reactogenicity of viral vaccines.
Janak A Patel; Sangeeta Nair; Eliana E Ochoa; Ruksana Huda; Norbert J Roberts; Tasnee Chonmaitree
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-25
Journal Detail:
Title:  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research     Volume:  30     ISSN:  1557-7465     ISO Abbreviation:  J. Interferon Cytokine Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-06-15     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9507088     Medline TA:  J Interferon Cytokine Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  917-21     Citation Subset:  IM    
Division of Pediatric Infectious Disease and Immunology, Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555-0371, USA.
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MeSH Terms
Interleukin-6 / biosynthesis*,  genetics*,  immunology
Macrophages / immunology,  metabolism,  virology*
Polymorphism, Single Nucleotide / genetics*,  immunology
Respiratory Syncytial Viruses / immunology*,  isolation & purification
Tumor Necrosis Factor-alpha / biosynthesis*,  genetics*,  immunology
Grant Support
Reg. No./Substance:
0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

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