Document Detail


Interleukin-4 polymorphisms in early onset periodontitis.
MedLine Citation:
PMID:  11350513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND, AIMS: Periodontitis is the result of a complex interplay between oral bacteria and the host response, often modulated by behavioral factors. Early-onset periodontitis (EOP) is defined by the age of onset, the distribution of lesions and specific microbial pathogens. METHOD: Studies in twins suggested a genetic contribution to the pathogenesis of periodontitis. EOP heritable factors may be related to immune mechanisms which could enhance the pathogenic potential of plaque bacteria in susceptible individuals. Among others, Interleukin 4 (IL-4) is a potent cytokine in the immune response and is a potent down regulator of macrophage function. In the present study, we report a specific genotype of the IL-4 gene, which was detected by specific primers and PCR analysis. RESULTS: In the EOP-group 27.8% were IL-4 promotor- and intron polymorphism positive (PP+ and IP+). None of the age-matched healthy controls or patients with adult periodontitis (n=25) carried the markers. Moreover, serum IL-4 levels of PP+ and IP+ patients were below the detection limit and significantly different (p<0.01) from the IL-4 concentrations of healthy controls and PP- and IP- patients.
Authors:
J Michel; J R Gonzáles; D Wunderlich; A Diete; J M Herrmann; J Meyle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  28     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-15     Completed Date:  2001-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  483-8     Citation Subset:  D; IM    
Affiliation:
Department of Periodontology, University of Giessen, Germany. joerg.michel@gen.bio.uni-giessen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aggressive Periodontitis / genetics,  immunology*
Alveolar Bone Loss / immunology
Case-Control Studies
DNA Primers
Dental Plaque / microbiology
Dental Plaque Index
Disease Susceptibility
Down-Regulation / immunology
Genetic Markers / genetics
Genotype
Gingival Hemorrhage / immunology
Humans
Interleukin-4 / blood,  genetics*
Introns / genetics
Macrophages / immunology
Periodontal Attachment Loss / immunology
Periodontal Index
Periodontal Pocket / immunology
Periodontitis / genetics,  immunology
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Genetic Markers; 207137-56-2/Interleukin-4

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