Document Detail

Interleukin-33: a novel mediator with a role in distinct disease pathologies.
MedLine Citation:
PMID:  21158975     Owner:  NLM     Status:  MEDLINE    
Interleukin-33 (IL-33) is a novel member of IL-1 cytokine family. It can act both as a nuclear factor and as a soluble mediator; however, the precise role of IL-33 within the nucleus is still not clear. As a cytokine, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage. As such, IL-33 targets multiple cell types thereby alerting the immune system to endogenous trauma such as physical stress or infection. However, a dysregulated release of IL-33 has a potential to drive distinct pathologies. In this review, we discuss the contribution of IL-33 to the pathophysiology of asthma, arthritis, obesity and atherosclerosis as well as the potential of IL-33 for therapeutic intervention.
M Kurowska-Stolarska; A Hueber; B Stolarski; I B McInnes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of internal medicine     Volume:  269     ISSN:  1365-2796     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-01-25     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Copyright Information:
© 2010 The Association for the Publication of the Journal of Internal Medicine.
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MeSH Terms
Arthritis / immunology
Asthma / immunology
Atherosclerosis / immunology
Hypersensitivity / immunology
Inflammation / immunology*
Interleukins / immunology*
Obesity / immunology
Grant Support
19213//Arthritis Research UK
Reg. No./Substance:
0/IL33 protein, human; 0/Interleukins

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