| Interleukin-33: a novel mediator with a role in distinct disease pathologies. | |
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MedLine Citation:
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PMID: 21158975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin-33 (IL-33) is a novel member of IL-1 cytokine family. It can act both as a nuclear factor and as a soluble mediator; however, the precise role of IL-33 within the nucleus is still not clear. As a cytokine, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage. As such, IL-33 targets multiple cell types thereby alerting the immune system to endogenous trauma such as physical stress or infection. However, a dysregulated release of IL-33 has a potential to drive distinct pathologies. In this review, we discuss the contribution of IL-33 to the pathophysiology of asthma, arthritis, obesity and atherosclerosis as well as the potential of IL-33 for therapeutic intervention. |
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Authors:
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M Kurowska-Stolarska; A Hueber; B Stolarski; I B McInnes |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of internal medicine Volume: 269 ISSN: 1365-2796 ISO Abbreviation: J. Intern. Med. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-16 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM |
Copyright Information:
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© 2010 The Association for the Publication of the Journal of Internal Medicine. |
Affiliation:
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Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis
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immunology Asthma / immunology Atherosclerosis / immunology Humans Hypersensitivity / immunology Inflammation / immunology* Interleukins / immunology* Obesity / immunology |
| Chemical | |
Reg. No./Substance:
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0/IL33 protein, human; 0/Interleukins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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