Document Detail

Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis.
MedLine Citation:
PMID:  23331679     Owner:  NLM     Status:  In-Data-Review    
Background -  Interleukin-31 (IL-31) is a member of the gp130/interleukin-6 cytokine family that is produced by cell types such as T helper 2 lymphocytes and cutaneous lymphocyte antigen positive skin homing T cells. When overexpressed in transgenic mice, IL-31 induces severe pruritus, alopecia and skin lesions. In humans, IL-31 serum levels correlate with the severity of atopic dermatitis in adults and children. Hypothesis/Objective -  To determine the role of IL-31 in canine pruritus and naturally occurring canine atopic dermatitis (AD). Animals -  Purpose-bred beagle dogs were used for laboratory studies. Serum samples were obtained from laboratory animals, nondiseased client-owned dogs and client-owned dogs diagnosed with naturally occurring AD. Methods -  Purpose-bred beagle dogs were administered canine interleukin-31 (cIL-31) via several routes (intravenous, subcutaneous or intradermal), and pruritic behaviour was observed/quantified via video monitoring. Quantitative immunoassay techniques were employed to measure serum levels of cIL-31 in dogs. Results -  Injection of cIL-31 into laboratory beagle dogs caused transient episodes of pruritic behaviour regardless of the route of administration. When evaluated over a 2 h period, dogs receiving cIL-31 exhibited a significant increase in pruritic behaviour compared with dogs that received placebo. In addition, cIL-31 levels were detectable in 57% of dogs with naturally occurring AD (≥13 pg/mL) but were below limits of quantification (<13 pg/mL) in normal, nondiseased laboratory or client-owned animals. Conclusions -  Canine IL-31 induced pruritic behaviours in dogs. Canine IL-31 was detected in the majority of dogs with naturally occurring AD, suggesting that this cytokine may play an important role in pruritic allergic skin conditions, such as atopic dermatitis, in this species.
Andrea J Gonzales; William R Humphrey; James E Messamore; Timothy J Fleck; Gregory J Fici; John A Shelly; Janet F Teel; Gary F Bammert; Steven A Dunham; Troy E Fuller; Robert B McCall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary dermatology     Volume:  24     ISSN:  1365-3164     ISO Abbreviation:  Vet. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426187     Medline TA:  Vet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  48-e12     Citation Subset:  IM    
Copyright Information:
© 2013 Pfizer Inc. Veterinary Dermatology © 2013 ESVD and ACVD.
Global Therapeutics Research, Pfizer Animal Health, Kalamazoo, MI 49001, USA.
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