| Interleukin-29 suppresses hepatitis a and C viral internal ribosomal entry site-mediated translation. | |
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MedLine Citation:
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PMID: 23035851 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Our aim was to investigate the effects of interferons (IFNs)-λ (interleukin-29 [IL-29], IL-28A, and IL-28B) on hepatitis C virus (HCV) and hepatitis A virus (HAV) internal ribosomal entry site (IRES)-mediated translation. The effects of these IFNs on HCV/HAV translation from HAV/HCV IRES were investigated using bicistronic reporter constructs. We transfected HCV/HAV IRES constructs into these IFN-expressing cell lines. IL-29 showed stronger inhibition of their IRES-mediated translation. Combining IL-29 with IFN-α or amantadine resulted in stronger inhibition of HAV IRES activity. Our findings demonstrated a novel antiviral effect of IFNs-λ against HAV and HCV through the suppression of IRES-mediated translation. |
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Authors:
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Tatsuo Kanda; Shuang Wu; Tomoko Kiyohara; Shingo Nakamoto; Xia Jiang; Tatsuo Miyamura; Fumio Imazeki; Koji Ishii; Takaji Wakita; Osamu Yokosuka |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Viral immunology Volume: 25 ISSN: 1557-8976 ISO Abbreviation: Viral Immunol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801552 Medline TA: Viral Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 379-86 Citation Subset: IM |
Affiliation:
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1 Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine , Chiba, Japan . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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