Document Detail

Interleukin-29 suppresses hepatitis a and C viral internal ribosomal entry site-mediated translation.
MedLine Citation:
PMID:  23035851     Owner:  NLM     Status:  In-Data-Review    
Abstract Our aim was to investigate the effects of interferons (IFNs)-λ (interleukin-29 [IL-29], IL-28A, and IL-28B) on hepatitis C virus (HCV) and hepatitis A virus (HAV) internal ribosomal entry site (IRES)-mediated translation. The effects of these IFNs on HCV/HAV translation from HAV/HCV IRES were investigated using bicistronic reporter constructs. We transfected HCV/HAV IRES constructs into these IFN-expressing cell lines. IL-29 showed stronger inhibition of their IRES-mediated translation. Combining IL-29 with IFN-α or amantadine resulted in stronger inhibition of HAV IRES activity. Our findings demonstrated a novel antiviral effect of IFNs-λ against HAV and HCV through the suppression of IRES-mediated translation.
Tatsuo Kanda; Shuang Wu; Tomoko Kiyohara; Shingo Nakamoto; Xia Jiang; Tatsuo Miyamura; Fumio Imazeki; Koji Ishii; Takaji Wakita; Osamu Yokosuka
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Viral immunology     Volume:  25     ISSN:  1557-8976     ISO Abbreviation:  Viral Immunol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801552     Medline TA:  Viral Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-86     Citation Subset:  IM    
1 Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine , Chiba, Japan .
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