| Interleukin-26: an IL-10-related cytokine produced by Th17 cells. | |
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MedLine Citation:
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PMID: 20947410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-γ) and IL22 (IL-22). IL-26 is often co-expressed with IL-22 by activated T cells, especially Th17 cells. It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains. IL-26 receptors are primarily expressed on non-hematopoietic cell types, particularly epithelial cells. Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes. The biological functions of IL-26 have only begun to be defined. |
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Authors:
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Raymond P Donnelly; Faruk Sheikh; Harold Dickensheets; Ram Savan; Howard A Young; Mark R Walter |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review Date: 2010-10-14 |
Journal Detail:
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Title: Cytokine & growth factor reviews Volume: 21 ISSN: 1879-0305 ISO Abbreviation: Cytokine Growth Factor Rev. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-03-10 Revised Date: 2011-10-14 |
Medline Journal Info:
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Nlm Unique ID: 9612306 Medline TA: Cytokine Growth Factor Rev Country: England |
Other Details:
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Languages: eng Pagination: 393-401 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ltd. |
Affiliation:
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Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA. Raymond.Donnelly@fda.hhs.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Interleukin-10 / biosynthesis, genetics Interleukins / biosynthesis*, genetics* Th17 Cells / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI47300/AI/NIAID NIH HHS; AI47300-08S/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/IL26 protein, human; 0/Interleukins; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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